Combined effect of astaxanthin and squalene on oxidative stress in vivo

Kumar, Sangeetha Ravi; Narayan, Bhaskar; Sawada, Yuki; Hosokawa, Masashi; Miyashita, Kazuo

Combined effect of astaxanthin and squalene on oxidative stress in vivo

Kumar, Sangeetha Ravi; Narayan, Bhaskar; Sawada, Yuki et al.

Molecular and cellular biochemistry, 2016, 417(1-2), 57-65

Permalink : https://hdl.handle.net/2115/65792

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アクセス権	open access
URI	https://hdl.handle.net/2115/65792
タイトル	Combined effect of astaxanthin and squalene on oxidative stress in vivo
著者	Kumar, Sangeetha Ravi ; Narayan, Bhaskar ; Sawada, Yuki ; Hosokawa, Masashi ; Miyashita, Kazuo
著者名 Kumar, Sangeetha Ravi
著者名 Narayan, Bhaskar
著者名 Sawada, Yuki
e-Rad_Researcher 10241374 著者名 Hosokawa, Masashi
e-Rad_Researcher 10182015 著者名 Miyashita, Kazuo
言語	英語
キーワード	Antioxidant enzymes
	Astaxanthin
	KK-A(y) mice
	Lipid hydroperoxides
	Squalene
発行日	2016-06
出版者	Springer
収録物名	Molecular and cellular biochemistry
巻(号)	417(1-2)
ページ	57-65
抄録	Obesity and diabetes, risk factors for metabolic syndrome, are characterized by oxidative stress and inflammatory responses. Marine biofunctionals, astaxanthin (Ax) and squalene (SQ), were evaluated for their combined effect. Groups of male KK-A (y) mice were fed high fat/sucrose diet for 4 weeks, supplemented with either 0.1 %Ax, 2 %SQ or 0.1 %Ax + 2 %SQ. In comparison to control, Sod was elevated in only Ax + SQ. However, Gpx was highest in Ax + SQ, indicating the combined antioxidant effect of Ax and SQ. This was supported by elevated mRNA expression of Sod1 and Gpx1. Except adiponectin (elevated in Ax and Ax + SQ), expression of other inflammatory markers was not altered. Blood glucose levels were decreased in SQ and Ax + SQ while liver triglycerides decreased in SQ group. This is the first in vivo study demonstrating combined effects of Ax and SQ resulting in antioxidant effects and modulation of glucose/triglyceride levels. This study highlights the benefit of utilizing Ax and SQ together for management of obesity/diabetes.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The final publication is available at link.springer.com
PISSN	0300-8177
EISSN	1573-4919
NCID	AA00745800
関連情報	PMID 27188184
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s11010-016-2713-2