open access

https://hdl.handle.net/2115/65832

Effects of infant flow Bi-NCPAP on apnea of prematurity

英語

tracheal intubation

2016-06

Wiley-Blackwell

Pediatrics international

58(6)

456-460

Background: Infant flow biphasic nasal continuous positive airway pressure (Bi-NCPAP) and regular NCPAP (Re-NCPAP) are equally useful with respect to the rate of successful weaning from mechanical ventilation. It remains unclear, however, whether Bi-NCPAP or Re-NCPAP is more effective for reducing apnea of prematurity (AOP). Methods: A multicenter randomized controlled study was conducted of 66 infants assigned to receive Bi-NCPAP and 66 assigned to receive Re-NCPAP for respiratory support after extubation. Primary outcome was the number of AOP events during the 48 h observation period after successful extubation, defined as no reintubation and no adverse events associated with the use of NCPAP during the observation period. The secondary outcome was successful extubation. Reintubation was at the discretion of the attending physician. Results: Baseline characteristics were similar between the two groups. The number of AOP events during the 48 h observation period was significantly lower in infants with Bi-NCPAP than in those with Re-NCPAP (5.2 ± 6.5 vs 10.3 ± 10.9 per infant, respectively; P = 0.002). The rate of successful extubation tended to be greater in those with Bi-NCPAP than in those with Re-NCPAP (92.4%, 61/66 vs 80.3%, 53/66, respectively; P = 0.074). Adverse events occurred in only one of 132 infants: erosive dermatitis developed on the nose after application of Re-NCPAP. The risk of reintubation did not differ significantly between the two groups (7.6%, 5/66 for Bi-NCPAP vs 18.2%, 12/66 for Re-NCPAP; P = 0.117). Conclusions: Bi-NCPAP was superior to Re-NCPAP for reduction of AOP following extubation.

学術雑誌論文

Accepted Manuscript

This is the peer reviewed version of the following article: Ishihara, C., Ibara, S., Ohsone, Y., Kato, E., Tokuhisa, T., Yamamoto, Y., Maede, Y., Kuwahara, T., and Minakami, H. (2016) Effects of infant flow Bi-NCPAP on apnea of prematurity. Pediatrics International, 58: 456–460, which has been published in final form at http://dx.doi.org/10.1111/ped.12854. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

1328-8067