Rhodium-Catalyzed Enantioselective Arylation of Aliphatic Imines

Kato, Naoya; Shirai, Tomohiko; Yamamoto, Yasunori

Chemistry-A European journal, 2016, 22(23), 7739-7742

Permalink : https://hdl.handle.net/2115/65861

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アクセス権	open access
URI	https://hdl.handle.net/2115/65861
タイトル	Rhodium-Catalyzed Enantioselective Arylation of Aliphatic Imines
著者	Kato, Naoya ; Shirai, Tomohiko ; Yamamoto, Yasunori
著者名 Kato, Naoya
著者名 Shirai, Tomohiko
e-Rad_Researcher 30271646 著者名 Yamamoto, Yasunori
言語	英語
キーワード	asymmetric arylation
	cationic rhodium
	imines
	phosphoramidite
	alpha-branched amine
発行日	2016-06-01
出版者	Wiley-Blackwell
収録物名	Chemistry-A European journal
巻(号)	22(23)
ページ	7739-7742
抄録	Chiral rhodium(I)-catalyzed highly enantioselective arylation of aliphatic N-sulfonyl aldimines with arylboronic acids has been developed. This transformation is achieved by the use of a rhodium/bis(phosphoramidite) catalyst to give enantiomerically enriched a-branched amines (up to 99% ee). In addition, this system enables efficient synthesis of (+)-NPS R-568 and Cinacalcet which are calcimimetic agents.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is the peer reviewed version of the following article: Chemistry A European journal, 22(23) June 1 2016 Pages 7739–7742 , which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/chem.201601246/abstract. This article may be used for non-commercial purposes in accordance With Wiley-VCH Terms and Conditions for self-archiving.
PISSN	0947-6539
関連情報	PMID 27119262
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1002/chem.201601246