Prediction of response to remission induction therapy by gene expression profiling of peripheral blood in Japanese patients with microscopic polyangiitis

Ishizu, Akihiro; Tomaru, Utano; Masuda, Sakiko; Sada, Ken-ei; Amano, Koichi; Harigai, Masayoshi; Kawaguchi, Yasushi; Arimura, Yoshihiro; Yamagata, Kunihiro; Ozaki, Shoichi; Dobashi, Hiroaki; Homma, Sakae; Okada, Yasunori; Sugiyama, Hitoshi; Usui, Joichi; Tsuboi, Naotake; Matsuo, Seiichi; Makino, Hirofumi

Prediction of response to remission induction therapy by gene expression profiling of peripheral blood in Japanese patients with microscopic polyangiitis

Ishizu, Akihiro; Tomaru, Utano; Masuda, Sakiko et al.

Arthritis Research & Therapy, 2017, 19, 117

Permalink : https://hdl.handle.net/2115/66002

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アクセス権	open access
URI	https://hdl.handle.net/2115/66002
タイトル	Prediction of response to remission induction therapy by gene expression profiling of peripheral blood in Japanese patients with microscopic polyangiitis
著者	Ishizu, Akihiro ; Tomaru, Utano ; Masuda, Sakiko ; Sada, Ken-ei ; Amano, Koichi ; Harigai, Masayoshi ; Kawaguchi, Yasushi ; Arimura, Yoshihiro ; Yamagata, Kunihiro ; Ozaki, Shoichi ; Dobashi, Hiroaki ; Homma, Sakae ; Okada, Yasunori ; Sugiyama, Hitoshi ; Usui, Joichi ; Tsuboi, Naotake ; Matsuo, Seiichi ; Makino, Hirofumi
e-Rad_Researcher 60321957 著者名 Ishizu, Akihiro
e-Rad_Researcher 20360901 著者名 Tomaru, Utano
著者名 Masuda, Sakiko
著者名 Sada, Ken-ei
著者名 Amano, Koichi
e-Rad_Researcher 20238207 著者名 Harigai, Masayoshi
e-Rad_Researcher 60292984 著者名 Kawaguchi, Yasushi
著者名 Arimura, Yoshihiro
e-Rad_Researcher 90312850 著者名 Yamagata, Kunihiro
e-Rad_Researcher 00231233 著者名 Ozaki, Shoichi
著者名 Dobashi, Hiroaki
著者名 Homma, Sakae
e-Rad_Researcher 00115221 著者名 Okada, Yasunori
著者名 Sugiyama, Hitoshi
著者名 Usui, Joichi
著者名 Tsuboi, Naotake
著者名 Matsuo, Seiichi
e-Rad_Researcher 50165685 著者名 Makino, Hirofumi
言語	英語
キーワード	Microscopic polyangiitis
	Prediction of response to treatment
	Gene profiling
	Peripheral blood
発行日	2017-05-31
出版者	BioMed Central
収録物名	Arthritis Research & Therapy
巻(号)	19
ページ	117
抄録	Background: Microscopic polyangiitis (MPA), which is classified as an anti-neutrophil cytoplasmic antibody (ANCA)- associated small vessel vasculitis, is one of the most frequent primary vasculitides in Japan. We earlier nominated 16 genes (IRF7, IFIT1, IFIT5, OASL, CLC, GBP-1, PSMB9, HERC5, CCR1, CD36, MS4A4A, BIRC4BP, PLSCR1, DEFA1/DEFA3, DEFA4, and COL9A2) as predictors of response to remission induction therapy against MPA. The aim of this study is to determine the accuracy of prediction using these 16 predictors. Methods: Thirty-nine MPA patients were selected randomly and retrospectively from the Japanese nationwide RemIT-JAV-RPGN cohort and enrolled in this study. Remission induction therapy was conducted according to the Guidelines of Treatment for ANCA-Associated Vasculitis published by the Ministry of Health, Labour, and Welfare of Japan. Response to remission induction therapy was predicted by profiling the altered expressions of the 16 predictors between the period before and 1 week after the beginning of treatment. Remission is defined as the absence of clinical manifestations of active vasculitis (Birmingham Vasculitis Activity Score 2003: 0 or 1 point). Persistent remission for 18 months is regarded as a “good response,” whereas no remission or relapse after remission is regarded as a “poor response.” Results: “Poor” and “good” responses were predicted in 7 and 32 patients, respectively. Five out of 7 patients with “poor” prediction and 1 out of 32 patients with “good” prediction experienced relapse after remission. One out of 7 patients with “poor” prediction was not conducted to remission. Accordingly, the sensitivity and specificity to predict poor response was 85.7% (6/7) and 96.9% (31/32), respectively. Conclusions: Response to remission induction therapy can be predicted by monitoring the altered expressions of the 16 predictors in the peripheral blood at an early point of treatment in MPA patients
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
EISSN	1478-6362
関連情報	PMID 28569178
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1186/s13075-017-1328-7