Aureobasidium pullulans produced β-glucan is effective to enhance Kurosengoku soybean extract induced Thrombospondin-1 expression

Muramatsu, Daisuke; Okabe, Mitsuyasu; Takaoka, Akinori; Kida, Hiroshi; Iwai, Atsushi

Aureobasidium pullulans produced β-glucan is effective to enhance Kurosengoku soybean extract induced Thrombospondin-1 expression

Muramatsu, Daisuke; Okabe, Mitsuyasu; Takaoka, Akinori et al.

Scientific Reports, 2017, 7(1), 2831

Permalink : https://hdl.handle.net/2115/66039

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アクセス権	open access
URI	https://hdl.handle.net/2115/66039
タイトル	Aureobasidium pullulans produced β-glucan is effective to enhance Kurosengoku soybean extract induced Thrombospondin-1 expression
著者	Muramatsu, Daisuke ; Okabe, Mitsuyasu ; Takaoka, Akinori ; Kida, Hiroshi ; Iwai, Atsushi
著者名 Muramatsu, Daisuke
著者名 Okabe, Mitsuyasu
e-Rad_Researcher 30323611 著者名 Takaoka, Akinori
e-Rad_Researcher 10109506 著者名 Kida, Hiroshi
著者名 Iwai, Atsushi
言語	英語
発行日	2017-06-06
出版者	Nature Publishing
収録物名	Scientific Reports
巻(号)	7(1)
ページ	2831
抄録	Black yeast, Aureobasidium pullulans is extracellularly produced β-(1,3), (1,6)-D-glucan (β-glucan) under certain conditions. In this study, using Glycine max cv. Kurosengoku (Kurosengoku soybeans), the production of β-glucan through fermentation of A. pullulans was evaluated, and the effects of A. pullulans cultured fluid (AP-CF) containing β-glucan made with Kurosengoku soybeans (kAP-CF) on a human monocyte derived cell line, Mono Mac 6 cells were investigated. Concentration of β-glucan in kAP-CF reached the same level as normal AP-CF. An anti-angiogenic protein, Thrombospondin-1 (THBS1) was effectively induced after the stimulation with kAP-CF for comparison with AP-CF. The THBS1 is also induced after stimulation with hot water extract of Kurosengoku soybeans (KS-E), while the combined stimulation of β-glucan with KS-E more effectively induced THBS1 than that with KS-E alone. These results suggest effects of A. pullulans-produced β-glucan on the enhancement of Kurosengoku soybean-induced THBS1 expression.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
EISSN	2045-2322
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1038/s41598-017-03053-9