The Short- and Long-Term Outcome of Intratympanic Steroid Therapy as a Salvage Treatment for Acute Low-Tone Sensorineural Hearing Loss without Episodes of Vertigo

Morita, Shinya; Nakamaru, Yuji; Fujiwara, Keishi; Iizuka, Keiji; Masuya, Masayori; Homma, Akihiro; Fukuda, Atsushi; Fukuda, Satoshi

The Short- and Long-Term Outcome of Intratympanic Steroid Therapy as a Salvage Treatment for Acute Low-Tone Sensorineural Hearing Loss without Episodes of Vertigo

Morita, Shinya; Nakamaru, Yuji; Fujiwara, Keishi et al.

Audiology & neuro-otology, 2016, 21(3), 132-140

Permalink : https://hdl.handle.net/2115/66407

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アクセス権	open access
URI	https://hdl.handle.net/2115/66407
タイトル	The Short- and Long-Term Outcome of Intratympanic Steroid Therapy as a Salvage Treatment for Acute Low-Tone Sensorineural Hearing Loss without Episodes of Vertigo
その他のタイトル	Intratympanic steroid therapy for ALHL
著者	Morita, Shinya ; Nakamaru, Yuji ; Fujiwara, Keishi ; Iizuka, Keiji ; Masuya, Masayori ; Homma, Akihiro ; Fukuda, Atsushi ; Fukuda, Satoshi
著者名 Morita, Shinya
e-Rad_Researcher 20344509 著者名 Nakamaru, Yuji
著者名 Fujiwara, Keishi
著者名 Iizuka, Keiji
著者名 Masuya, Masayori
e-Rad_Researcher 30312359 著者名 Homma, Akihiro
著者名 Fukuda, Atsushi
e-Rad_Researcher 20125347 著者名 Fukuda, Satoshi
言語	英語
キーワード	Intratympanic steroid therapy
	Outcome
	Acute low-tone sensorineural hearing loss
	Recurrence
	Ménière’s disease
発行日	2016-07
出版者	Karger
収録物名	Audiology & neuro-otology
巻(号)	21(3)
ページ	132-140
抄録	Objectives: To evaluate the hearing outcomes of intratympanic steroid (ITS) treatment for patients with acute low-tone sensorineural hearing loss (ALHL) after failure of initial therapy and to investigate the recurrence and progression to definite Ménière's disease (MD) during a long-term follow-up. Methods: We retrospectively reviewed the medical records of 90 patients with refractory ALHL who were followed up for at least 1 year between January 2000 and April 2014. Patients who responded poorly to initial medical treatment received intratympanic dexamethasone injections (ITS group) or isosorbide administration for 4 weeks (diuretic group) as salvage treatment options according to their choice of management. The control group did not receive ITS or the diuretic, due to their refusal of both medical treatments. The hearing outcomes were evaluated 1 month, 1 year and 5 years after the completion of the second-line therapy, and the rates of recurrence and progression to MD were measured during a follow-up period of at least 1 year. Results: Twenty-seven patients in the ITS group, 39 patients in the diuretic group and 24 patients in the control group were enrolled. Of these, 12 patients in the ITS group, 15 patients in the diuretic group and 12 patients in the control group were followed up for over 5 years. We found that the recovery rates and the audiometric functional values after 1 month and 1 year in the ITS group were significantly higher than those in the diuretic and control groups. However, there were no significant differences in the recovery rates or the audiometric functional values after 5 years, or in the rates of recurrence and progression to MD between the groups. Conclusions: Salvage ITS therapy can provide a relatively good short-term hearing outcome for ALHL patients who have persistent hearing loss despite conventional treatment. However, both recurrence and progression to MD after treatment were observed in some patients during the long-term follow-up.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is the peer-reviewed but unedited manuscript version of the following article: Audiol Neurotol 2016;21:132-140 (DOI: 10.1159/000444577). The final, published version is available at http://www.karger.com/?doi=10.1159/000444577
PISSN	1420-3030
関連情報	PMID 27077389
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1159/000444577