Reduced-dose methotrexate in combination with tacrolimus was associated with rapid engraftment and recovery from oral mucositis without affecting the incidence of GVHD

Matsukawa, Toshihiro; Hashimoto, Daigo; Sugita, Junichi; Nakazawa, Seitarou; Matsushita, Takae; Kashiwazaki, Haruhiko; Goto, Hideki; Onozawa, Masahiro; Kahata, Kaoru; Fujimoto, Katsuya; Endo, Tomoyuki; Kondo, Takeshi; Hashino, Satoshi; Yamazaki, Yutaka; Teshima, Takanori

Reduced-dose methotrexate in combination with tacrolimus was associated with rapid engraftment and recovery from oral mucositis without affecting the incidence of GVHD

Matsukawa, Toshihiro; Hashimoto, Daigo; Sugita, Junichi et al.

International journal of hematology, 2016, 104(1), 117-124

Permalink : https://hdl.handle.net/2115/66415

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アクセス権	open access
URI	https://hdl.handle.net/2115/66415
タイトル	Reduced-dose methotrexate in combination with tacrolimus was associated with rapid engraftment and recovery from oral mucositis without affecting the incidence of GVHD
著者	Matsukawa, Toshihiro ; Hashimoto, Daigo ; Sugita, Junichi ; Nakazawa, Seitarou ; Matsushita, Takae ; Kashiwazaki, Haruhiko ; Goto, Hideki ; Onozawa, Masahiro ; Kahata, Kaoru ; Fujimoto, Katsuya ; Endo, Tomoyuki ; Kondo, Takeshi ; Hashino, Satoshi ; Yamazaki, Yutaka ; Teshima, Takanori
著者名 Matsukawa, Toshihiro
著者名 Hashimoto, Daigo
著者名 Sugita, Junichi
著者名 Nakazawa, Seitarou
著者名 Matsushita, Takae
e-Rad_Researcher 10344516 著者名 Kashiwazaki, Haruhiko
著者名 Goto, Hideki
e-Rad_Researcher 70455632 著者名 Onozawa, Masahiro
著者名 Kahata, Kaoru
著者名 Fujimoto, Katsuya
著者名 Endo, Tomoyuki
e-Rad_Researcher 70333606 著者名 Kondo, Takeshi
e-Rad_Researcher 60271665 著者名 Hashino, Satoshi
e-Rad_Researcher 90250464 著者名 Yamazaki, Yutaka
e-Rad_Researcher 40284096 著者名 Teshima, Takanori
言語	英語
キーワード	GVHD prophylaxis
	Methotrexate
	Oral mucositis
	Engraftment
発行日	2016-07
出版者	Springer
収録物名	International journal of hematology
巻(号)	104(1)
ページ	117-124
抄録	Allogeneic hematopoietic stem cell transplantation is a curable treatment for hematological diseases. Graft-versus-host disease (GVHD) causes morbidity and mortality after HSCT. Methotrexate (MTX) is used for GVHD prophylaxis, but its appropriate dose remains unclear. In the present study, we compared the efficacy and toxicity of 15-10-10 MTX (day +1: 15 mg/m2; days +3 and +6: 10 mg/m2) with 10-7-7 MTX (day +1: 10 mg/m2; day +3 and +6: 7 mg/m2) in combination with tacrolimus. The cumulative incidence rates of grades II-IV acute GVHD, grades III-IV acute GVHD and chronic GVHD in the 15-10-10 MTX and 10-7-7 MTX groups did not differ to a statistically significant extent. The median time for neutrophil engraftment in the 15-10-10 MTX group was 16 days (range, 11-31 days), while that in the 10-7-7 group was 15 days (range, 12-19 days) (P = 0.024). Moreover, the median time for platelet recovery was significantly shorter in the 10-7-7 MTX group (22 days; range, 13-49 days) than that in the 15-10-10 MTX group (27 days; range, 9-405 days) (P = 0.027). The duration of oral mucositis was significantly shorter in the patients who received a reduced dose of MTX (median, 4.5 vs 13.0 days; P = 0.013). In conclusion, GVHD prophylaxis with a reduced dose of MTX was associated with earlier engraftment and earlier recovery from mucositis in comparison to a standard dose of MTX, without affecting the incidence of GVHD.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The final publication is available at link.springer.com
PISSN	0925-5710
関連情報	PMID 27119977
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s12185-016-1996-0