Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post-translationally Modified Peptide Ustiloxin B in Filamentous Fungi

Ye, Ying; Minami, Atsushi; Igarashi, Yuya; Izumikawa, Miho; Umemura, Myco; Nagano, Nozomi; Machida, Masayuki; Kawahara, Teppei; Shin-ya, Kazuo; Gomi, Katsuya; Oikawa, Hideaki

Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post-translationally Modified Peptide Ustiloxin B in Filamentous Fungi

Ye, Ying; Minami, Atsushi; Igarashi, Yuya et al.

Angewandte chemie-international edition, 2016, 55(28), 8072-8075

Permalink : https://hdl.handle.net/2115/66438

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アクセス権	open access
URI	https://hdl.handle.net/2115/66438
タイトル	Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post-translationally Modified Peptide Ustiloxin B in Filamentous Fungi
著者	Ye, Ying ; Minami, Atsushi ; Igarashi, Yuya ; Izumikawa, Miho ; Umemura, Myco ; Nagano, Nozomi ; Machida, Masayuki ; Kawahara, Teppei ; Shin-ya, Kazuo ; Gomi, Katsuya ; Oikawa, Hideaki
著者名 Ye, Ying
著者名 Minami, Atsushi
著者名 Igarashi, Yuya
著者名 Izumikawa, Miho
著者名 Umemura, Myco
著者名 Nagano, Nozomi
著者名 Machida, Masayuki
著者名 Kawahara, Teppei
著者名 Shin-ya, Kazuo
著者名 Gomi, Katsuya
e-Rad_Researcher 00185175 著者名 Oikawa, Hideaki
言語	英語
キーワード	biosynthesis
	heterologous expression
	natural products
	RiPPs
	ustiloxins
発行日	2016-07-04
出版者	Wiley-Blackwell
収録物名	Angewandte chemie-international edition
巻(号)	55(28)
ページ	8072-8075
抄録	The biosynthetic machinery of the first fungal ribosomally synthesized and post-translationally modified peptide (RiPP) ustiloxin B was elucidated through a series of gene inactivation and heterologous expression studies. The results confirmed an essential requirement for novel oxidases possessing the DUF3328 motif for macrocyclization, and highly unique side-chain modifications by three oxidases (UstCF1F2) and a pyridoxal 5'-phosphate (PLP)-dependent enzyme (UstD). These findings provide new insight into the expression of the RiPP gene clusters found in various fungi.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is the peer reviewed version of the following article: Y. Ye, A. Minami, Y. Igarashi, M. Izumikawa, M. Umemura, N. Nagano, M. Machida, T. Kawahara, K. Shin-ya, K. Gomi, H. Oikawa, Angew. Chem. Int. Ed. 2016, 55, 8072, which has been published in final form at doi:10.1002/anie.201602611. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
PISSN	1433-7851
関連情報	PMID 27166860
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1002/anie.201602611