Insulin-like growth factor-1, IGF binding protein-3, and the risk of esophageal cancer in a nested case-control study

Adachi, Yasushi; Nojima, Masanori; Mori, Mitsuru; Yamashita, Kentaro; Yamano, Hiro-o; Nakase, Hiroshi; Endo, Takao; Wakai, Kenji; Sakata, Kiyomi; Tamakoshi, Akiko

Insulin-like growth factor-1, IGF binding protein-3, and the risk of esophageal cancer in a nested case-control study

Adachi, Yasushi; Nojima, Masanori; Mori, Mitsuru et al.

World Journal of Gastroenterology, 2017, 23(19), 3488-3495

Permalink : https://hdl.handle.net/2115/66888

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アクセス権	open access
URI	https://hdl.handle.net/2115/66888
タイトル	Insulin-like growth factor-1, IGF binding protein-3, and the risk of esophageal cancer in a nested case-control study
著者	Adachi, Yasushi ; Nojima, Masanori ; Mori, Mitsuru ; Yamashita, Kentaro ; Yamano, Hiro-o ; Nakase, Hiroshi ; Endo, Takao ; Wakai, Kenji ; Sakata, Kiyomi ; Tamakoshi, Akiko
著者名 Adachi, Yasushi
著者名 Nojima, Masanori
e-Rad_Researcher 50175634 著者名 Mori, Mitsuru
著者名 Yamashita, Kentaro
著者名 Yamano, Hiro-o
著者名 Nakase, Hiroshi
著者名 Endo, Takao
e-Rad_Researcher 50270989 著者名 Wakai, Kenji
e-Rad_Researcher 50225794 著者名 Sakata, Kiyomi
e-Rad_Researcher 90236737 著者名 Tamakoshi, Akiko
言語	英語
キーワード	Esophageal cancer
	Insulin-like growth factor
	Insulin-like growth factor binding protein
	Nested case-control study
	Odds ratio
発行日	2017-05-21
出版者	Baishideng Publishing Group
収録物名	World Journal of Gastroenterology
巻(号)	23(19)
ページ	3488-3495
抄録	AIM: To assess the relationship between serum levels of insulin-like growth factor-1 (IGF1)/IGF-binding protein-3 (IGFBP3) and the risk of esophageal carcinoma. METHODS: We assessed the relationship between the serum levels of these molecules and the risk of esophageal cancer in a prospective, nested case-control study of participants from the Japan Collaborative Cohort Study. A baseline survey was conducted from 1988 to 1990. Of the 110585 enrolled participants, 35% donated blood samples. Those who had been diagnosed with esophageal cancer were considered cases for nested case-control studies. A conditional logistic model was used to estimate odds ratios for the incidence of esophageal cancer associated with serum IGF1 and IGFBP3 levels. RESULTS: Thirty-one cases and 86 controls were eligible for the present assessment. The molar ratio of IGF1/IGFBP3, which represents the free and active form of IGF1, was not correlated with the risk of esophageal carcinoma. A higher molar difference between IGFBP3 and IGF1, which estimates the free form of IGFBP3, was associated with a decreased risk of esophageal carcinoma (P = 0.0146), and people in the highest tertile had the lowest risk (OR = 0.107, 95% CI: 0.017-0.669). After adjustment for body mass index, tobacco use, and alcohol intake, the molar difference of IGFBP3-IGF1 was inversely correlated with the risk of esophageal carcinoma (P = 0.0150). CONCLUSION: The free form of IGFBP3, which is estimated by this molar difference, may be inversely associated with esophageal cancer incidence.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial 4.0 International
PISSN	1007-9327
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3748/wjg.v23.i19.3488