p53 represses the transcription of snRNA genes by preventing the formation of little elongation complex

Anwar, Delnur; Takahashi, Hidehisa; Watanabe, Masashi; Suzuki, Masanobu; Fukuda, Satoshi; Hatakeyama, Shigetsugu

p53 represses the transcription of snRNA genes by preventing the formation of little elongation complex

Anwar, Delnur; Takahashi, Hidehisa; Watanabe, Masashi et al.

Biochimica et biophysica acta. Gene regulatory mechanisms, 2016, 1859(8), 975-982

Permalink : https://hdl.handle.net/2115/66903

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アクセス権	open access
URI	https://hdl.handle.net/2115/66903
タイトル	p53 represses the transcription of snRNA genes by preventing the formation of little elongation complex
著者	Anwar, Delnur ; Takahashi, Hidehisa ; Watanabe, Masashi ; Suzuki, Masanobu ; Fukuda, Satoshi ; Hatakeyama, Shigetsugu
著者名 Anwar, Delnur
e-Rad_Researcher 30423544 著者名 Takahashi, Hidehisa
著者名 Watanabe, Masashi
著者名 Suzuki, Masanobu
e-Rad_Researcher 20125347 著者名 Fukuda, Satoshi
e-Rad_Researcher 70294973 著者名 Hatakeyama, Shigetsugu
言語	英語
キーワード	p53
	ELL
	Transcription
	snRNA
	LEC
発行日	2016-08
出版者	Elsevier
収録物名	Biochimica et biophysica acta. Gene regulatory mechanisms
巻(号)	1859(8)
ページ	975-982
抄録	The regulation of transcription by RNA polymerase II (Pol II) is important for a variety of cellular functions. ELL/EAF-containing little elongation complex (LEC) was found to be required for transcription of Pol II-dependent small nuclear RNA (snRNA) genes. It was shown that the tumor suppressor p53 interacts with ELL and inhibits transcription elongation activity of ELL Here, we show that p53 inhibits interaction between ELL/EAF and ICE1 in LEC and thereby p53 represses transcription of Pol II-dependent snRNA genes through inhibiting LEC function. Furthermore, induction of p53 expression by ultraviolet (UV) irradiation decreases the occupancy of ICE1 at Pol II-dependent snRNA genes. Consistent with the results, knockdown of p53 increased both the expression of snRNA genes and the occupancy of Pol II and components of LEC at snRNA genes. Our results indicate that p53 interferes with the interaction between ELL/EAF and ICE1 and represses transcription of snRNA genes by Pol II.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	1874-9399
関連情報	PMID 27268141
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.bbagrm.2016.06.001