Combination of soya pulp and Bacillus coagulans lilac-01 improves intestinal bile acid metabolism without impairing the effects of prebiotics in rats fed a cholic acid-supplemented diet

Lee, Yeonmi; Yoshitsugu, Reika; Kikuchi, Keidai et al.

British journal of nutrition, 2016, 116(4), 603-610

Permalink : https://hdl.handle.net/2115/66932

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アクセス権
open access
URI
https://hdl.handle.net/2115/66932
タイトル
Combination of soya pulp and Bacillus coagulans lilac-01 improves intestinal bile acid metabolism without impairing the effects of prebiotics in rats fed a cholic acid-supplemented diet
著者
Lee, Yeonmi ; Yoshitsugu, Reika ; Kikuchi, Keidai ; Joe, Ga-Hyun ; Tsuji, Misaki ; Nose, Takuma ; Shimizu, Hidehisa ; Hara, Hiroshi ; Minamida, Kimiko ; Miwa, Kazunori ; Ishizuka, Satoshi
著者名
Lee, Yeonmi
著者名
Yoshitsugu, Reika
著者名
Kikuchi, Keidai
著者名
Joe, Ga-Hyun
著者名
Tsuji, Misaki
著者名
Nose, Takuma
著者名
Shimizu, Hidehisa
e-Rad_Researcher
70198894
著者名
Hara, Hiroshi
著者名
Minamida, Kimiko
著者名
Miwa, Kazunori
e-Rad_Researcher
00271627
著者名
Ishizuka, Satoshi
言語
英語
キーワード
Bile acids
Soya pulp
Bacillus coagulans lilac-01
Synbiotics
Gut permeability
発行日
2016-08
出版者
Cambridge University Press
収録物名
British journal of nutrition
巻(号)
116(4)
ページ
603-610
抄録
Intestinal bacteria are involved in bile acid (BA) deconjugation and/ or dehydroxylation and are responsible for the production of secondary BA. However, an increase in the production of secondary BA modulates the intestinal microbiota due to the bactericidal effects and promotes cancer risk in the liver and colon. The ingestion of Bacillus coagulans improves constipation via the activation of bowel movement to promote defaecation in humans, which may alter BA metabolism in the intestinal contents. BA secretion is promoted with high-fat diet consumption, and the ratio of cholic acid (CA): chenodeoxycholic acid in primary BA increases with ageing. The dietary supplementation of CA mimics the BA environment in diet-induced obesity and ageing. We investigated whether B. coagulans lilac-01 and soya pulp influence both BA metabolism and the maintenance of host health in CA-supplemented diet-fed rats. In CA-fed rats, soya pulp significantly increased the production of secondary BA such as deoxycholic acid and omega-muricholic acids, and soya pulp ingestion alleviated problems related to plasma adiponectin and gut permeability in rats fed the CA diet. The combination of B. coagulans and soya pulp successfully suppressed the increased production of secondary BA in CA-fed rats compared with soya pulp itself, without impairing the beneficial effects of soya pulp ingestion. In conclusion, it is possible that a combination of prebiotics and probiotics can be used to avoid an unnecessary increase in the production of secondary BA in the large intestine without impairing the beneficial functions of prebiotics.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution 4.0 International
PISSN
0007-1145
EISSN
1475-2662
NCID
AA00574708
関連情報
PMID
27464459
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1017/S0007114516002270