Type XVII collagen coordinates proliferation in the interfollicular epidermis

Watanabe, Mika; Natsuga, Ken; Nishie, Wataru; Kobayashi, Yasuaki; Donati, Giacomo; Suzuki, Shotaro; Fujimura, Yu; Tsukiyama, Tadasuke; Ujiie, Hideyuki; Shinkuma, Satoru; Nakamura, Hideki; Murakami, Masamoto; Ozaki, Michitaka; Nagayama, Masaharu; Watt, Fiona M; Shimizu, Hiroshi

Type XVII collagen coordinates proliferation in the interfollicular epidermis

Watanabe, Mika; Natsuga, Ken; Nishie, Wataru et al.

Elife, 2017, 6, e26635

Permalink : https://hdl.handle.net/2115/67060

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アクセス権	open access
URI	https://hdl.handle.net/2115/67060
タイトル	Type XVII collagen coordinates proliferation in the interfollicular epidermis
著者	Watanabe, Mika ; Natsuga, Ken ; Nishie, Wataru ; Kobayashi, Yasuaki ; Donati, Giacomo ; Suzuki, Shotaro ; Fujimura, Yu ; Tsukiyama, Tadasuke ; Ujiie, Hideyuki ; Shinkuma, Satoru ; Nakamura, Hideki ; Murakami, Masamoto ; Ozaki, Michitaka ; Nagayama, Masaharu ; Watt, Fiona M ; Shimizu, Hiroshi
著者名 Watanabe, Mika
e-Rad_Researcher 70645457 著者名 Natsuga, Ken
e-Rad_Researcher 20443955 著者名 Nishie, Wataru
著者名 Kobayashi, Yasuaki
著者名 Donati, Giacomo
著者名 Suzuki, Shotaro
著者名 Fujimura, Yu
e-Rad_Researcher 20399819 著者名 Tsukiyama, Tadasuke
e-Rad_Researcher 60374435 著者名 Ujiie, Hideyuki
e-Rad_Researcher 00613788 著者名 Shinkuma, Satoru
e-Rad_Researcher 60435956 著者名 Nakamura, Hideki
著者名 Murakami, Masamoto
e-Rad_Researcher 80256510 著者名 Ozaki, Michitaka
e-Rad_Researcher 20314289 著者名 Nagayama, Masaharu
著者名 Watt, Fiona M
e-Rad_Researcher 00146672 著者名 Shimizu, Hiroshi
言語	英語
発行日	2017-07-11
出版者	eLife Sciences Publications
収録物名	Elife
巻(号)	6
ページ	e26635
抄録	Type XVII collagen (COL17) is a transmembrane protein located at the epidermal basement membrane zone. COL17 deficiency results in premature hair aging phenotypes and in junctional epidermolysis bullosa. Here, we show that COL17 plays a central role in regulating interfollicular epidermis (IFE) proliferation. Loss of COL17 leads to transient IFE hypertrophy in neonatal mice owing to aberrant Wnt signaling. The replenishment of COL17 in the neonatal epidermis of COL17-null mice reverses the proliferative IFE phenotype and the altered Wnt signaling. Physical aging abolishes membranous COL17 in IFE basal cells because of inactive atypical protein kinase C signaling and also induces epidermal hyperproliferation. The overexpression of human COL17 in aged mouse epidermis suppresses IFE hypertrophy. These findings demonstrate that COL17 governs IFE proliferation of neonatal and aged skin in distinct ways. Our study indicates that COL17 could be an important target of anti-aging strategies in the skin.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	2050-084X
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.7554/eLife.26635