The immunosuppressive effect of domain-deleted dimer of HLA-G2 isoform in collagen-induced arthritis mice

Takahashi, Ami; Kuroki, Kimiko; Okabe, Yuki; Kasai, Yoshiyuki; Matsumoto, Naoki; Yamada, Chisato; Takai, Toshiyuki; Ose, Toyoyuki; Kon, Shigeyuki; Matsuda, Tadashi; Maenaka, Katsumi

The immunosuppressive effect of domain-deleted dimer of HLA-G2 isoform in collagen-induced arthritis mice

Takahashi, Ami; Kuroki, Kimiko; Okabe, Yuki et al.

Human immunology, 2016, 77(9), 754-759

Permalink : https://hdl.handle.net/2115/67073

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アクセス権	open access
URI	https://hdl.handle.net/2115/67073
タイトル	The immunosuppressive effect of domain-deleted dimer of HLA-G2 isoform in collagen-induced arthritis mice
著者	Takahashi, Ami ; Kuroki, Kimiko ; Okabe, Yuki ; Kasai, Yoshiyuki ; Matsumoto, Naoki ; Yamada, Chisato ; Takai, Toshiyuki ; Ose, Toyoyuki ; Kon, Shigeyuki ; Matsuda, Tadashi ; Maenaka, Katsumi
著者名 Takahashi, Ami
e-Rad_Researcher 90553313 著者名 Kuroki, Kimiko
著者名 Okabe, Yuki
著者名 Kasai, Yoshiyuki
著者名 Matsumoto, Naoki
著者名 Yamada, Chisato
e-Rad_Researcher 20187917 著者名 Takai, Toshiyuki
e-Rad_Researcher 80380525 著者名 Ose, Toyoyuki
e-Rad_Researcher 90344499 著者名 Kon, Shigeyuki
e-Rad_Researcher 20212219 著者名 Matsuda, Tadashi
e-Rad_Researcher 10322752 著者名 Maenaka, Katsumi
言語	英語
キーワード	HLA-G2
	LILRB2/ILT4
	PIR-B
	CIA mice
	Immunosuppression
発行日	2016-09
出版者	Elsevier
収録物名	Human immunology
巻(号)	77(9)
ページ	754-759
抄録	HLA-G is involved in maternal-fetal immune tolerance and is reported to be a natural tolerogenic molecule. Seven-spliced isoforms including dimeric and beta 2m-free forms have been identified. The major isoform, HLA-G1 (and its soluble type HLA-G5), binds to the inhibitory immune receptors, leukocyte immunoglobulin (Ig)-like receptor (LILR) B1 and LILRB2. We previously reported that HLA-G1 also binds to paired Ig-like receptor (PIR)-B, a mouse homolog of LILRBs, and had a significant immunosuppressive effect in collagen-induced arthritis (CIA) mice. Although HLA-G2 and its soluble form HLA-G6 bind specifically to LILRB2, its functional characteristics are largely unknown. In this study, we report the significant immunosuppressive effect of HLA-G2 dimer in CIA mice. Surface plasmon resonance analysis revealed a specific interaction of HLA-G2 with PIR-B. CIA mice were administered HLA-G2 protein subcutaneously once in the left footpad and clinical severity was evaluated in a double-blind study. A single administration of HLA-G2 maintained a suppressive effect for over 1 month. These results suggested that the HLA-G2 protein might be a useful biopharmaceutical for the treatment of rheumatoid arthritis by binding to inhibitory PIR-B. (C) 2016 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0198-8859
関連情報	PMID 26805457
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.humimm.2016.01.010