Genetic and antigenic characterization of H5, H6 and H9 avian influenza viruses circulating in live bird markets with intervention in the center part of Vietnam

Duc-Huy Chu; Okamatsu, Masatoshi; Matsuno, Keita et al.

Veterinary Microbiology, 2016, 192, 194-203

Permalink : https://hdl.handle.net/2115/67102

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アクセス権
open access
URI
https://hdl.handle.net/2115/67102
タイトル
Genetic and antigenic characterization of H5, H6 and H9 avian influenza viruses circulating in live bird markets with intervention in the center part of Vietnam
著者
Duc-Huy Chu ; Okamatsu, Masatoshi ; Matsuno, Keita ; Hiono, Takahiro ; Ogasawara, Kohei ; Lam Thanh Nguyen ; Long Van Nguyen ; Tien Ngoc Nguyen ; Thuy Thu Nguyen ; Dong Van Pham ; Dang Hoang Nguyen ; Tho Dang Nguyen ; Thanh Long To ; Hung Van Nguyen ; Kida, Hiroshi ; Sakoda, Yoshihiro
著者名
Duc-Huy Chu
e-Rad_Researcher
00507163
著者名
Okamatsu, Masatoshi
e-Rad_Researcher
40753306
著者名
Matsuno, Keita
著者名
Hiono, Takahiro
著者名
Ogasawara, Kohei
著者名
Lam Thanh Nguyen
著者名
Long Van Nguyen
著者名
Tien Ngoc Nguyen
著者名
Thuy Thu Nguyen
著者名
Dong Van Pham
著者名
Dang Hoang Nguyen
著者名
Tho Dang Nguyen
著者名
Thanh Long To
著者名
Hung Van Nguyen
e-Rad_Researcher
10109506
著者名
Kida, Hiroshi
e-Rad_Researcher
40333637
著者名
Sakoda, Yoshihiro
言語
英語
キーワード
Avian influenza
Antigenic analysis
Phylogenetic analysis
Live bird market
Surveillance
発行日
2016-08-31
出版者
Elsevier
収録物名
Veterinary Microbiology
巻(号)
192
ページ
194-203
抄録
A total of 3,045 environmental samples and oropharyngeal and cloacal swabs from apparently healthy poultry have been collected at three live bird markets (LBMs) at which practices were applied to reduce avian influenza (AI) virus transmission (intervention LBMs) and six conventional LBMs (non-intervention LBMs) in Thua Thien Hue province in 2014 to evaluate the efficacy of the intervention LBMs. The 178 AI viruses, including H3 (19 viruses), H4 (2), H5 (8), H6 (30), H9 (114), and H11 (5), were isolated from domestic ducks, muscovy ducks, chickens, and the environment. The prevalence of AI viruses in intervention LBMs (6.1%; 95% CI: 5.0-7.5) was similar to that in non-intervention LBMs (5.6%; 95% CI: 4.5-6.8; x(2) = 0.532; df = 1; P = 0.53) in the study area. Eight H5N6 highly pathogenic avian influenza (HPAI) viruses were isolated from apparently healthy ducks, muscovy ducks, and an environmental sample in an intervention LBM. The hemagglutinin genes of the H5N6 HPAI viruses belonged to the genetic Glade 23.4.4, and the antigenicity of the H5N6 HPAI viruses differed from the H5N1 HPAI viruses previously circulating in Vietnam. Phylogenetic and antigenic analyses of the H6 and H9 viruses isolated in both types of LBMs revealed that they were closely related to the viruses isolated from domestic birds in China, Group II of H6 viruses and Y280 lineage of H9 viruses. These results indicate that the interventions currently applied in LBMs are insufficient to control AI. A risk analysis should be conducted to identify the key factors contributing to Al virus prevalence in intervention LBMs. (C) 2016 Elsevier B.V. All rights reserved.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報
©2016, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN
0378-1135
EISSN
1873-2542
NCID
AA00883633
関連情報
PMID
27527783
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.vetmic.2016.07.016