Combined effects of AHR, CYP1A1, and XRCC1 genotypes and prenatal maternal smoking on infant birth size : Biomarker assessment in the Hokkaido Study

Kobayashi, Sumitaka; Sata, Fumihiro; Sasaki, Seiko; Braimoh, Titilola Serifat; Araki, Atsuko; Miyashita, Chihiro; Goudarzi, Houman; Kobayashi, Sachiko; Kishi, Reiko

Combined effects of AHR, CYP1A1, and XRCC1 genotypes and prenatal maternal smoking on infant birth size : Biomarker assessment in the Hokkaido Study

Kobayashi, Sumitaka; Sata, Fumihiro; Sasaki, Seiko et al.

Reproductive Toxicology, 2016, 65, 295-306

Permalink : https://hdl.handle.net/2115/67220

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アクセス権	open access
URI	https://hdl.handle.net/2115/67220
タイトル	Combined effects of AHR, CYP1A1, and XRCC1 genotypes and prenatal maternal smoking on infant birth size : Biomarker assessment in the Hokkaido Study
著者	Kobayashi, Sumitaka ; Sata, Fumihiro ; Sasaki, Seiko ; Braimoh, Titilola Serifat ; Araki, Atsuko ; Miyashita, Chihiro ; Goudarzi, Houman ; Kobayashi, Sachiko ; Kishi, Reiko
e-Rad_Researcher 10733371 著者名 Kobayashi, Sumitaka
著者名 Sata, Fumihiro
e-Rad_Researcher 30448831 著者名 Sasaki, Seiko
著者名 Braimoh, Titilola Serifat
e-Rad_Researcher 00619885 著者名 Araki, Atsuko
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
e-Rad_Researcher 40713607 著者名 Goudarzi, Houman
著者名 Kobayashi, Sachiko
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
キーワード	Maternal smoking
	Aromatic hydrocarbon receptor (AHR)
	Cytochrome P450 1A1 (CYP1A1)
	X-ray–complementing gene 1 (XRCC1)
	Birth size
発行日	2016-10
出版者	Elsevier
収録物名	Reproductive Toxicology
巻(号)	65
ページ	295-306
抄録	Objectives: We investigated the individual and combined effects of maternal polymorphisms encoding the aromatic hydrocarbon receptor (AHR; rs2066853), cytochrome P450 (CYP) 1A1 (rs1048963), and the X-ray-complementing gene 1 (XRCC1; rs1799782) and prenatal smoking in relation to infant birth size. Methods: Totally, 3263 participants (1998 non-smokers and 1265 smokers) were included in the study between 2003 and 2007. Two groups of mothers were distinguished by plasma cotinine levels by ELISA measured during the third trimester (cut-off = 11.48 ng/mL). We conducted data analysis using multiple linear regression models. Results: Infants whose mothers smoked and had AHR-GG, CYP1A1-AG/GG, and XRCC1-CT/TT genotypes weighed, -145 g less than those born of mothers who did not smoke and had the AHR-GA/AA, CYP1A1-AA, and XRCC1-CC genotypes (95% CI: -241, -50). Conclusions: We demonstrated that infants whose mothers smoked during pregnancy with the combination of AHR, CYP1A1, and XRCC1 polymorphisms had lower birth size.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0890-6238
関連情報	PMID 27592400
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.reprotox.2016.08.020