Chemotherapy-Induced IL34 Enhances Immunosuppression by Tumor-Associated Macrophages and Mediates Survival of Chemoresistant Lung Cancer Cells

Baghdadi, Muhammad; Wada, Haruka; Nakanishi, Sayaka; Abe, Hirotake; Han, Nanumi; Putra, Wira Eka; Endo, Daisuke; Watari, Hidemichi; Sakuragi, Noriaki; Hida, Yasuhiro; Kaga, Kichizo; Miyagi, Yohei; Yokose, Tomoyuki; Takano, Atsushi; Daigo, Yataro; Seino, Ken-ichiro

Chemotherapy-Induced IL34 Enhances Immunosuppression by Tumor-Associated Macrophages and Mediates Survival of Chemoresistant Lung Cancer Cells

Baghdadi, Muhammad; Wada, Haruka; Nakanishi, Sayaka et al.

Cancer research, 2016, 76(20), 6030-6042

Permalink : https://hdl.handle.net/2115/67225

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/67225
タイトル	Chemotherapy-Induced IL34 Enhances Immunosuppression by Tumor-Associated Macrophages and Mediates Survival of Chemoresistant Lung Cancer Cells
その他のタイトル	An importance of IL-34 in cancer chemoresistance
著者	Baghdadi, Muhammad ; Wada, Haruka ; Nakanishi, Sayaka ; Abe, Hirotake ; Han, Nanumi ; Putra, Wira Eka ; Endo, Daisuke ; Watari, Hidemichi ; Sakuragi, Noriaki ; Hida, Yasuhiro ; Kaga, Kichizo ; Miyagi, Yohei ; Yokose, Tomoyuki ; Takano, Atsushi ; Daigo, Yataro ; Seino, Ken-ichiro
著者名 Baghdadi, Muhammad
e-Rad_Researcher 70392181 著者名 Wada, Haruka
著者名 Nakanishi, Sayaka
著者名 Abe, Hirotake
著者名 Han, Nanumi
著者名 Putra, Wira Eka
著者名 Endo, Daisuke
e-Rad_Researcher 10344508 著者名 Watari, Hidemichi
e-Rad_Researcher 70153963 著者名 Sakuragi, Noriaki
e-Rad_Researcher 30399919 著者名 Hida, Yasuhiro
e-Rad_Researcher 80224335 著者名 Kaga, Kichizo
e-Rad_Researcher 00254194 著者名 Miyagi, Yohei
著者名 Yokose, Tomoyuki
e-Rad_Researcher 50582607 著者名 Takano, Atsushi
e-Rad_Researcher 30345029 著者名 Daigo, Yataro
e-Rad_Researcher 20312845 著者名 Seino, Ken-ichiro
言語	英語
発行日	2016-10
出版者	American Association for Cancer Research
収録物名	Cancer research
巻(号)	76(20)
ページ	6030-6042
抄録	The ability of tumor cells to escape immune destruction and their acquired resistance to chemotherapy are major obstacles to effective cancer therapy. Although immune checkpoint therapies such as anti-PD-1 address these issues in part, clinical responses remain limited to a subpopulation of patients. In this report, we identified IL34 produced by cancer cells as a driver of chemoresistance. In particular, we found that IL34 modulated the functions of tumor-associated macrophages to enhance local immunosuppression and to promote the survival of chemoresistant cancer cells by activating AKT signaling. Targeting IL34 in chemoresistant tumors resulted in a remarkable inhibition of tumor growth when accompanied with chemotherapy. Our results define a pathogenic role for IL34 in mediating immunosuppression and chemoresistance and identify it as a tractable target for anticancer therapy.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0008-5472
関連情報	PMID 27550451
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1158/0008-5472.CAN-16-1170