Serum myostatin levels are independently associated with skeletal muscle wasting in patients with heart failure

Furihata, Takaaki; Kinugawa, Shintaro; Fukushima, Arata; Takada, Shingo; Homma, Tsuneaki; Masaki, Yoshihiro; Abe, Takahiro; Yokota, Takashi; Oba, Koji; Okita, Koichi; Tsutsui, Hiroyuki

Serum myostatin levels are independently associated with skeletal muscle wasting in patients with heart failure

Furihata, Takaaki; Kinugawa, Shintaro; Fukushima, Arata et al.

International journal of cardiology, 2016, 220, 483-487

Permalink : https://hdl.handle.net/2115/67234

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アクセス権	open access
URI	https://hdl.handle.net/2115/67234
タイトル	Serum myostatin levels are independently associated with skeletal muscle wasting in patients with heart failure
著者	Furihata, Takaaki ; Kinugawa, Shintaro ; Fukushima, Arata ; Takada, Shingo ; Homma, Tsuneaki ; Masaki, Yoshihiro ; Abe, Takahiro ; Yokota, Takashi ; Oba, Koji ; Okita, Koichi ; Tsutsui, Hiroyuki
e-Rad_Researcher 60782505 著者名 Furihata, Takaaki
e-Rad_Researcher 60399871 著者名 Kinugawa, Shintaro
e-Rad_Researcher 40706553 著者名 Fukushima, Arata
e-Rad_Researcher 60722329 著者名 Takada, Shingo
著者名 Homma, Tsuneaki
著者名 Masaki, Yoshihiro
著者名 Abe, Takahiro
e-Rad_Researcher 90374321 著者名 Yokota, Takashi
e-Rad_Researcher 30422926 著者名 Oba, Koji
e-Rad_Researcher 80382539 著者名 Okita, Koichi
e-Rad_Researcher 70264017 著者名 Tsutsui, Hiroyuki
言語	英語
キーワード	Heart failure
	Myostatin
	Muscle wasting
発行日	2016-10-01
出版者	Elsevier
収録物名	International journal of cardiology
巻(号)	220
ページ	483-487
抄録	Background: It has been reported that skeletal muscle mass and strength are decreased in patients with heart failure (HF), and HF is associated with both reduced exercise capacity and adverse clinical outcomes. Myostatin has been known as a negative regulator of muscle growth, follistatin as the myostatin antagonist, maintaining tissue homeostasis. We thus determined serum myostatin levels in HF patients and whether they are associated with skeletal muscle wasting. Methods and results: Forty one consecutive HF patients (58 +/- 15 years old, New York Heart Association class I-III) and 30 age-matched healthy subjects as controls (53 +/- 8 years old) were studied. Serum myostatin levels were significantly lower in HF patients than controls (18.7 +/- 7.4 vs. 23.6 +/- 5.2 ng/mL, P < 0.001). Circumference of the thickest part of the right thigh was significantly small (468 +/- 72 vs. 559 +/- 37 mm, P = 0.001) and lower extremity muscular strength was lower in patients with HF (129 +/- 55 vs. 219 +/- 52 N × m, P < 0.001). Fourteen HF patients (34%) had muscle wasting. By univariate analysis, higher age, higher serum follistatin, and lower serum myostatin were significantly associated with the presence of muscle wasting. By multivariate analysis, serum myostatin levels were independently associated with muscle wasting (OR = 0.77, 95% CI [0.58, 0.93], P = 0.02). Conclusion: Serum myostatin levels were significantly decreased in HF patients and associated with lower extremity muscle wasting, suggesting that myostatin may be an important factor for maintaining skeletal muscle mass and strength in HF.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0167-5273
関連情報	PMID 27390974
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.ijcard.2016.06.231