Glucose tolerance is improved following surgery for silent somatotroph adenoma

Miya, Aika; Nakamura, Akinobu; Miyoshi, Hideaki; Kameda, Hiraku; Nomoto, Hiroshi; Nagai, So; Omori, Yuko; Hatanaka, Kanako C.; Kobayashi, Hiroyuki; Shimizu, Chikara; Atsumi, Tatsuya

Glucose tolerance is improved following surgery for silent somatotroph adenoma

Miya, Aika; Nakamura, Akinobu; Miyoshi, Hideaki et al.

International Journal of Diabetes and Clinical Research, 2015, 2(6), 047

Permalink : https://hdl.handle.net/2115/67262

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アクセス権	open access
URI	https://hdl.handle.net/2115/67262
タイトル	Glucose tolerance is improved following surgery for silent somatotroph adenoma
著者	Miya, Aika ; Nakamura, Akinobu ; Miyoshi, Hideaki ; Kameda, Hiraku ; Nomoto, Hiroshi ; Nagai, So ; Omori, Yuko ; Hatanaka, Kanako C. ; Kobayashi, Hiroyuki ; Shimizu, Chikara ; Atsumi, Tatsuya
著者名 Miya, Aika
e-Rad_Researcher 70552420 著者名 Nakamura, Akinobu
e-Rad_Researcher 30360902 著者名 Miyoshi, Hideaki
著者名 Kameda, Hiraku
著者名 Nomoto, Hiroshi
e-Rad_Researcher 70507590 著者名 Nagai, So
著者名 Omori, Yuko
著者名 Hatanaka, Kanako C.
著者名 Kobayashi, Hiroyuki
e-Rad_Researcher 00292029 著者名 Shimizu, Chikara
e-Rad_Researcher 20301905 著者名 Atsumi, Tatsuya
言語	英語
キーワード	Silent somatotroph adenoma
	glucose tolerance
	oral glucose tolerance test
	insulin sensitivity
発行日	2015
出版者	ClinMed International Library
収録物名	International Journal of Diabetes and Clinical Research
巻(号)	2(6)
ページ	047
抄録	Although the excessive secretion of GH leads to insulin resistance enhancement, the involvement of a silent somatotroph adenoma in abnormal glucose tolerance has not been elucidated. A 50 - year-old man was admitted with a headache and bitemporal hemianopia caused by a pituitary macroadenoma. He had no physical signs and symptoms of acromegaly nor hypopituitarism, and his base-line serum levels of GH and insulin - like growth factor-1 (IGF-1) were normal. However, a 75 - g oral glucose tolerance test (OGTT) showed unsuppressed GH concentrations as well as plasma glucose levels consistent with diabetes pattern. A transsphenoidal adenomectomy was performed, and we diagnosed the patient as having a silent somatotroph adenoma based on positive GH in the immunohistochemistry. Postoperative OGTT showed GH suppression and a normal pattern of plasma glucose levels after glucose loading. The post-surgery homeostasis model assessment insulin resistance index (HOMA - IR) and the Matsuda Index indicated improved insulin sensitivity in the absence of perioperative body-mass-index change. These observations suggest that reversible abnormal glucose tolerance is associated with a silent somatotroph adenoma in this patient.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	2377-3634
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.23937/2377-3634/1410047