The role of lipid droplets in metabolic disease in rodents and humans

Greenberg, Andrew S.; Coleman, Rosalind A.; Kraemer, Fredric B. et al.

The Journal of clinical investigation, 2011, 121(6), 2102-2110

Permalink : https://hdl.handle.net/2115/67266

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アクセス権
open access
URI
https://hdl.handle.net/2115/67266
タイトル
The role of lipid droplets in metabolic disease in rodents and humans
著者
Greenberg, Andrew S. ; Coleman, Rosalind A. ; Kraemer, Fredric B. ; McManaman, James L. ; Obin, Martin S. ; Puri, Vishwajeet ; Yan, Qing-Wu ; Miyoshi, Hideaki ; Mashek, Douglas G.
著者名
Greenberg, Andrew S.
著者名
Coleman, Rosalind A.
著者名
Kraemer, Fredric B.
著者名
McManaman, James L.
著者名
Obin, Martin S.
著者名
Puri, Vishwajeet
著者名
Yan, Qing-Wu
e-Rad_Researcher
30360902
著者名
Miyoshi, Hideaki
著者名
Mashek, Douglas G.
言語
英語
発行日
2011-06-01
出版者
American Society for Clinical Investigation
収録物名
The Journal of clinical investigation
巻(号)
121(6)
ページ
2102-2110
抄録
Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells. Over the last two decades there has been a dramatic growth in our understanding of LD biology and, in parallel, our understanding of the role of LDs in health and disease. In its simplest form, the LD regulates the storage and hydrolysis of neutral lipids, including triacylglycerol and/or cholesterol esters. It is becoming increasingly evident that alterations in the regulation of LD physiology and metabolism influence the risk of developing metabolic diseases such as diabetes. In this review we provide an update on the role of LD-associated proteins and LDs in metabolic disease.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
0021-9738
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1172/JCI46069