Synapse-specific effects of IL-1β on long-term potentiation in the mouse hippocampus

Hoshino, Koji; Hasegawa, Kan; Kamiya, Haruyuki et al.

Biomedical Research, 2017, 38(3), 183-188

Permalink : https://hdl.handle.net/2115/67301

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アクセス権
open access
URI
https://hdl.handle.net/2115/67301
タイトル
Synapse-specific effects of IL-1β on long-term potentiation in the mouse hippocampus
著者
Hoshino, Koji ; Hasegawa, Kan ; Kamiya, Haruyuki ; Morimoto, Yuji
著者名
Hoshino, Koji
著者名
Hasegawa, Kan
e-Rad_Researcher
10194979
著者名
Kamiya, Haruyuki
e-Rad_Researcher
00250457
著者名
Morimoto, Yuji
言語
英語
発行日
2017-06
出版者
Biomedical Research Press
収録物名
Biomedical Research
巻(号)
38(3)
ページ
183-188
抄録
Interleukin-1β (IL-1β) is a key molecule in the inflammatory responses elicited during infection and injury. It exerts local effects on synaptic plasticity by binding to IL-1 receptors that are expressed at high levels in the hippocampus. We examined the effects of IL-1β on synaptic plasticity in different hippocampal regions in acute mouse brain slices by measuring long-term potentiation (LTP). IL-1β (1 ng/mL) was applied for 30 min before LTP was induced with high-frequency stimulation (HFS). LTP was significantly impaired by either IL-1β application to the Schaffer collateral- CA1 synapses or the associational/commissural (A/C) fiber-CA3 synapses, which are both dependent on N-methyl-D-aspartate (NMDA) receptor activation. However, mossy fiber-CA3 LTP, which is expressed presynaptically in an NMDA-independent manner, was not impaired by IL-1β. Our results demonstrate that IL-1β exerts variable effects on LTP at different kinds of synapses, indicating that IL-1β has synapse-specific effects on hippocampal synaptic plasticity.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
0388-6107
関連情報
PMID
28637953
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.2220/biomedres.38.183