Cellular function of osteocytes in normal and αklotho-deficient mice

Amizuka, Norio; Hasegawa, Tomoka; Yamamoto, Tomomaya; Mae, Takahito; Zixuan, Qiu; Abe, Miki; Shen, Zhao; Nagai, Tomoya; Yokoyama, Ayako; Naznin, Khadiza; Haraguchi, Mai; Yamamoto, Tsuneyuki; Freitas, Paulo Henrique Luiz de; Li, Minqi

Cellular function of osteocytes in normal and αklotho-deficient mice

Amizuka, Norio; Hasegawa, Tomoka; Yamamoto, Tomomaya et al.

北海道歯学雑誌, 2017, 38(Special issue), 56-62

Permalink : https://hdl.handle.net/2115/67337

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アクセス権	open access
URI	https://hdl.handle.net/2115/67337
タイトル	Cellular function of osteocytes in normal and αklotho-deficient mice
著者	Amizuka, Norio ; Hasegawa, Tomoka ; Yamamoto, Tomomaya ; Mae, Takahito ; Zixuan, Qiu ; Abe, Miki ; Shen, Zhao ; Nagai, Tomoya ; Yokoyama, Ayako ; Naznin, Khadiza ; Haraguchi, Mai ; Yamamoto, Tsuneyuki ; Freitas, Paulo Henrique Luiz de ; Li, Minqi
e-Rad_Researcher 30242431 著者名 Amizuka, Norio
著者名 Hasegawa, Tomoka
著者名 Yamamoto, Tomomaya
著者名 Mae, Takahito
著者名 Zixuan, Qiu
著者名 Abe, Miki
著者名 Shen, Zhao
著者名 Nagai, Tomoya
著者名 Yokoyama, Ayako
著者名 Naznin, Khadiza
著者名 Haraguchi, Mai
e-Rad_Researcher 80200822 著者名 Yamamoto, Tsuneyuki
著者名 Freitas, Paulo Henrique Luiz de
著者名 Li, Minqi
言語	英語
キーワード	osteocyte
	bone
	FGF23
	sclerostin
	αklotho
発行日	2017-09
出版者	北海道歯学会
出版者	Hokkaido association for dental science
収録物名	北海道歯学雑誌
収録物名	Hokkaido journal of dental science
巻(号)	38(Special issue)
ページ	56-62
抄録	During the last decade, osteocyte-derived factors i.e., sclerostin, dentin matrix protein-1, fibroblast growth factor 23 (FGF23) that reduces serum phosphate concentration by mediating FGF receptor 1c/αklotho in the kidney, have been highlighted for osteocytes’ fine-turned regulation on bone remodeling and phosphate homeostasis. Osteocytes are interconnected through gap junctions between their cytoplasmic processes, and thereby, build upon the functional syncytia, referred to as the osteocytic lacunar-canalicular system (OLCS). Osteocytes appear to communicate surrounding osteocytes and osteoblasts by means of two possible pathways of molecular transport throughout the OLCS : One is a passageway of their cytoplasmic processes, and the other is a pericellular space in the osteocytic canaliculi. The regularly-oriented OLCS in mature compact bone appears to efficiently serve for molecular transport, mechanosensing and targeted bone remodeling that would erase microdamages in bone. In a disrupted signaling state of FGF23/αklotho, serum concentration of phosphate would be markedly-elevated. Despite highly-elevated serum phosphate, αklotho -deficient mice revealed defective mineralization in bone matrix. OLCS in αklotho -deficient mice were irregularly-distributed and the connectivity of cytoplasmic processes of osteocytes was very poor, so that osteocytes did not seem to form functional syncytia. Therefore, osteocytes’function cooperated with other bone cells, rather than serum concentration of calcium/phosphate, and this seems to play a central role in maintaining bone mineralization. In this review, the biological function of the regularly-arranged OLCS in a normal state will be introduced, as well as dysfunctional osteocytes in αklotho-deficient state, using animal models.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0914-7063
NCID	AN00229778