Localization of photoperiod responsive circadian oscillators in the mouse suprachiasmatic nucleus

Yoshikawa, Tomoko; Inagaki, Natsuko F.; Takagi, Seiji; Kuroda, Shigeru; Yamasaki, Miwako; Watanabe, Masahiko; Honma, Sato; Honma, Ken-ichi

Localization of photoperiod responsive circadian oscillators in the mouse suprachiasmatic nucleus

Yoshikawa, Tomoko; Inagaki, Natsuko F.; Takagi, Seiji et al.

Scientific reports, 2017, 7, 8210

Permalink : https://hdl.handle.net/2115/67391

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/67391
タイトル	Localization of photoperiod responsive circadian oscillators in the mouse suprachiasmatic nucleus
著者	Yoshikawa, Tomoko ; Inagaki, Natsuko F. ; Takagi, Seiji ; Kuroda, Shigeru ; Yamasaki, Miwako ; Watanabe, Masahiko ; Honma, Sato ; Honma, Ken-ichi
e-Rad_Researcher 30451397 著者名 Yoshikawa, Tomoko
著者名 Inagaki, Natsuko F.
著者名 Takagi, Seiji
ORCID 0000-0002-8079-6322 著者名 Kuroda, Shigeru
e-Rad_Researcher 10431305 著者名 Yamasaki, Miwako
e-Rad_Researcher 70210945 著者名 Watanabe, Masahiko
e-Rad_Researcher 20142713 著者名 Honma, Sato
e-Rad_Researcher 40113625 著者名 Honma, Ken-ichi
言語	英語
発行日	2017-08-15
出版者	Nature Publishing Group
収録物名	Scientific reports
巻(号)	7
ページ	8210
抄録	The circadian pacemaker in the suprachiasmatic nucleus (SCN) yields photoperiodic response to transfer seasonal information to physiology and behavior. To identify the precise location involved in photoperiodic response in the SCN, we analyzed circadian Period1 and PERIOD2 rhythms in horizontally sectioned SCN of mice exposed to a long or short day. Statistical analyses of bioluminescence images with respective luciferase reporters on pixel level enabled us to identify the distinct localization of three oscillating regions; a large open-ring-shape region, the region at the posterior end and a sharply demarcated oval region at the center of the SCN. The first two regions are the respective sites for the so-called evening and morning oscillators, and the third region is possibly a site for mediating photic signals to the former oscillators. In these regions, there are two classes of oscillating cells in which Per1 and Per2 could play differential roles in photoperiodic responses.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	2045-2322
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1038/s41598-017-08186-5