Increased blood viscosity in ischemic stroke patients with small artery occlusion measured by an electromagnetic spinning sphere viscometer

Furukawa, Koji; Abumiya, Takeo; Sakai, Keiji; Hirano, Miki; Osanai, Toshiya; Shichinohe, Hideo; Nakayama, Naoki; Kazumata, Ken; Hida, Kazutoshi; Houkin, Kiyohiro

Increased blood viscosity in ischemic stroke patients with small artery occlusion measured by an electromagnetic spinning sphere viscometer

Furukawa, Koji; Abumiya, Takeo; Sakai, Keiji et al.

Journal of Stroke and Cerebrovascular Diseases, 2016, 25(11), 2762-2769

Permalink : https://hdl.handle.net/2115/67492

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アクセス権	open access
URI	https://hdl.handle.net/2115/67492
タイトル	Increased blood viscosity in ischemic stroke patients with small artery occlusion measured by an electromagnetic spinning sphere viscometer
著者	Furukawa, Koji ; Abumiya, Takeo ; Sakai, Keiji ; Hirano, Miki ; Osanai, Toshiya ; Shichinohe, Hideo ; Nakayama, Naoki ; Kazumata, Ken ; Hida, Kazutoshi ; Houkin, Kiyohiro
著者名 Furukawa, Koji
e-Rad_Researcher 80270726 著者名 Abumiya, Takeo
e-Rad_Researcher 00215584 著者名 Sakai, Keiji
著者名 Hirano, Miki
著者名 Osanai, Toshiya
e-Rad_Researcher 80374479 著者名 Shichinohe, Hideo
e-Rad_Researcher 40421961 著者名 Nakayama, Naoki
著者名 Kazumata, Ken
e-Rad_Researcher 10238305 著者名 Hida, Kazutoshi
e-Rad_Researcher 90229146 著者名 Houkin, Kiyohiro
言語	英語
キーワード	blood viscosity
	ischemic stroke
	small artery occlusion
	pathogenesis
	rheology
	dehydration
発行日	2016-11
出版者	Elsevier
収録物名	Journal of Stroke and Cerebrovascular Diseases
巻(号)	25(11)
ページ	2762-2769
抄録	Background and Purpose: High blood viscosity causes blood stagnation and subsequent pathological thrombotic events, resulting in the development of ischemic stroke. We hypothesize that the contribution of blood viscosity may differ among ischemic stroke subtypes based on specific pathological conditions. We tried to verify this hypothesis by measuring blood viscosity in acute ischemic stroke patients using a newly developed electromagnetic spinning sphere (EMS) viscometer. Methods: Measurements in acute ischemic stroke patients were performed 4 times during admission and data were compared with those obtained from 100 healthy outpatient volunteers. Results: We enrolled 92 patients (cardioembolism [CE]: 25, large-artery atherosclerosis [LAA]: 42, and small artery occlusion [SAO]: 25) in this study. Comparisons of blood viscosity between the ischemic stroke subgroups and control group revealed that blood viscosity at the date of admission was significantly higher in the SAO group (5.37±1.11 mPa・s) than in the control group (4.66±0.72 mPa・s) (p<0.01). Among all subtype groups showing a reduction in blood viscosity after 2 weeks, the SAO group showed the highest and most significant reduction, indicating that SAO patients had the most concentrated blood at the onset. Conclusions: Blood viscosity was significantly increased in the SAO group at the date of admission, which indicated the contribution of dehydration to the onset of ischemic stroke. The importance of dehydration needs to be emphasized more in the pathogenesis of SAO. The clinical application of the EMS viscometer is promising for understanding and differentiating the pathogenesis of ischemic stroke.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	1052-3057
関連情報	PMID 27503271
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.07.031