Clinicopathological factors predicting early and late distant recurrence in estrogen receptor-positive, HER2-negative breast cancer

Yamashita, Hiroko; Ogiya, Akiko; Shien, Tadahiko; Horimoto, Yoshiya; Masuda, Norikazu; Inao, Touko; Osako, Tomofumi; Takahashi, Masato; Endo, Yumi; Hosoda, Mitsuchika; Ishida, Naoko; Horii, Rie; Yamazaki, Kieko; Miyoshi, Yuichiro; Yasojima, Hiroyuki; Tomioka, Nobumoto; Collaborative Study Group of Scientific Research of the Japanese Breast Cancer Society

Clinicopathological factors predicting early and late distant recurrence in estrogen receptor-positive, HER2-negative breast cancer

Yamashita, Hiroko; Ogiya, Akiko; Shien, Tadahiko et al.

Breast cancer, 2016, 23(6), 830-843

Permalink : https://hdl.handle.net/2115/67497

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アクセス権	open access
URI	https://hdl.handle.net/2115/67497
タイトル	Clinicopathological factors predicting early and late distant recurrence in estrogen receptor-positive, HER2-negative breast cancer
著者	Yamashita, Hiroko ; Ogiya, Akiko ; Shien, Tadahiko ; Horimoto, Yoshiya ; Masuda, Norikazu ; Inao, Touko ; Osako, Tomofumi ; Takahashi, Masato ; Endo, Yumi ; Hosoda, Mitsuchika ; Ishida, Naoko ; Horii, Rie ; Yamazaki, Kieko ; Miyoshi, Yuichiro ; Yasojima, Hiroyuki ; Tomioka, Nobumoto ; Collaborative Study Group of Scientific Research of the Japanese Breast Cancer Society
e-Rad_Researcher 70332947 著者名 Yamashita, Hiroko
著者名 Ogiya, Akiko
e-Rad_Researcher 30509451 著者名 Shien, Tadahiko
著者名 Horimoto, Yoshiya
著者名 Masuda, Norikazu
著者名 Inao, Touko
著者名 Osako, Tomofumi
著者名 Takahashi, Masato
e-Rad_Researcher 20566228 著者名 Endo, Yumi
e-Rad_Researcher 40443931 著者名 Hosoda, Mitsuchika
著者名 Ishida, Naoko
e-Rad_Researcher 20446272 著者名 Horii, Rie
著者名 Yamazaki, Kieko
著者名 Miyoshi, Yuichiro
著者名 Yasojima, Hiroyuki
著者名 Tomioka, Nobumoto
著者名 Collaborative Study Group of Scientific Research of the Japanese Breast Cancer Society
言語	英語
キーワード	breast cancer
	late recurrence
	early recurrence
	estrogen receptor positive
	HER2 negative
	estrogen receptor-positive
	HER2-negative
発行日	2016-11
出版者	Springer
収録物名	Breast cancer
巻(号)	23(6)
ページ	830-843
抄録	Background: Most studies analyzing prognostic factors for late relapse have been performed in postmenopausal women who received tamoxifen or aromatase inhibitors as adjuvant endocrine therapy for estrogen receptor (ER)-positive breast cancer. Methods: A total of 223 patients (108 premenopausal and 115 postmenopausal) with early distant recurrence and 149 patients (62 premenopausal and 87 postmenopausal) with late distant recurrence of ER-positive, HER2-negative breast cancer who were given their initial treatment between 2000 and 2004 were registered from nine institutions. For each late recurrence patient, approximately two matched control patients without relapse for more than ten years were selected. Clinicopathological factors and adjuvant therapies were compared among the three groups by menopausal status and age. Results: Factors predicting early recurrence in premenopausal women were large tumor size, high lymph node category and high tumor grade, whereas predictors for late recurrence were large tumor size and high lymph node category. In postmenopausal women under 60 years of age, factors predicting early recurrence were bilateral breast cancer, large tumor size, high lymph node category, low PgR expression and high Ki67 labeling index (LI), while predictors for late recurrence were large tumor size and high lymph node category. On the other hand, in postmenopausal women aged 60 years or older, factors predicting early recurrence were bilateral breast cancer, large tumor size, high lymph node category, high tumor grade, low ER expression and high Ki67 LI, whereas predictors for late recurrence were high lymph node category, low ER expression and short duration of adjuvant endocrine therapy. Conclusion: Predictors of early and late distant recurrence might differ according to menopausal status and age.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The final publication is available at link.springer.com
PISSN	1340-6868
関連情報	PMID 26467036
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s12282-015-0649-0