Autoantibody profile differentiates between inflammatory and noninflammatory bullous pemphigoid

Izumi, Kentaro; Nishie, Wataru; Mai, Yosuke; Wada, Mayumi; Natsuga, Ken; Ujiie, Hideyuki; Iwata, Hiroaki; Yamagami, Jun; Shimizu, Hiroshi

Autoantibody profile differentiates between inflammatory and noninflammatory bullous pemphigoid

Izumi, Kentaro; Nishie, Wataru; Mai, Yosuke et al.

Journal of investigative dermatology, 2016, 136(11), 2201-2210

Permalink : https://hdl.handle.net/2115/67499

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/67499
タイトル	Autoantibody profile differentiates between inflammatory and noninflammatory bullous pemphigoid
その他のタイトル	Autoantibody profile differentiates between inflammatory and non-inflammatory bullous pemphigoid
その他のタイトル	Autoantibody profile differentiates BP phenotypes
著者	Izumi, Kentaro ; Nishie, Wataru ; Mai, Yosuke ; Wada, Mayumi ; Natsuga, Ken ; Ujiie, Hideyuki ; Iwata, Hiroaki ; Yamagami, Jun ; Shimizu, Hiroshi
e-Rad_Researcher 50793668 著者名 Izumi, Kentaro
e-Rad_Researcher 20443955 著者名 Nishie, Wataru
著者名 Mai, Yosuke
著者名 Wada, Mayumi
e-Rad_Researcher 70645457 著者名 Natsuga, Ken
e-Rad_Researcher 60374435 著者名 Ujiie, Hideyuki
e-Rad_Researcher 20397334 著者名 Iwata, Hiroaki
e-Rad_Researcher 80327618 著者名 Yamagami, Jun
e-Rad_Researcher 00146672 著者名 Shimizu, Hiroshi
言語	英語
キーワード	autoantibody
	bullous pemphigoid
	collagen XVII
	ELISA
	dipeptidyl peptidase-IV inhibitors
発行日	2016-11
出版者	Elsevier
収録物名	Journal of investigative dermatology
巻(号)	136(11)
ページ	2201-2210
抄録	Bullous pemphigoid (BP) is a major autoimmune blistering skin disorder, in which a majority of the autoantibodies (autoAbs) target the juxtamembranous extracellular noncollagenous 16A domain (NC16A) domain of hemidesmosomal collagen XVII. BP-autoAbs may target regions of collagen XVII other than the NC16A domain; however, correlations between epitopes of BP-autoAbs and clinical features have not been fully elucidated. To address correlations between the clinical features and specific epitopes of BP-autoAbs, we evaluated the epitope profiles of BP-autoAbs in 121 patients. A total of 87 patients showed a typical inflammatory phenotype with erythema and autoAbs targeting the anti-NC16A domain, whereas 14 patients showed a distinct noninflammatory phenotype, in which autoAbs specifically targeted the midportion of collagen XVII, but not NC16A. Interestingly, this group clinically showed significantly reduced erythema associated with scant lesional infiltration of eosinophils. Surprisingly, 7 of the 14 cases (50.0%) received dipeptidyl peptidase-IV inhibitors for the treatment of diabetes. Dipeptidyl peptidase-IV inhibitors were used in 3 of 76 (3.9%) typical cases of BP with autoAbs targeting NC16A; thus, dipeptidyl peptidase-IV inhibitors are thought to be involved in the development of atypical noninflammatory BP. This study shows that the autoAb profile differentiates between inflammatory and noninflammatory BP, and that noninflammatory BP may be associated with dipeptidyl peptidase-IV inhibitors.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0022-202X
関連情報	PMID 27424319
関連情報	URI http://www.jidonline.org/article/S0022-202X%2816%2932100-5/abstract
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.jid.2016.06.622