Local relapse of nasopharyngeal cancer and Voxel-based analysis of FMISO uptake using PET with semiconductor detectors

Nishikawa, Yukiko; Yasuda, Koichi; Okamoto, Shozo et al.

Radiation oncology, 2017, 12, 148

Permalink : https://hdl.handle.net/2115/67571

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論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/67571
タイトル
Local relapse of nasopharyngeal cancer and Voxel-based analysis of FMISO uptake using PET with semiconductor detectors
著者
Nishikawa, Yukiko ; Yasuda, Koichi ; Okamoto, Shozo ; Ito, Yoichi M. ; Onimaru, Rikiya ; Shiga, Tohru ; Tsuchiya, Kazuhiko ; Watanabe, Shiro ; Takeuchi, Wataru ; Kuge, Yuji ; Peng, Hao ; Tamaki, Nagara ; Shirato, Hiroki
著者名
Nishikawa, Yukiko
e-Rad_Researcher
00431362
著者名
Yasuda, Koichi
著者名
Okamoto, Shozo
e-Rad_Researcher
10334236
著者名
Ito, Yoichi M.
e-Rad_Researcher
80374461
著者名
Onimaru, Rikiya
e-Rad_Researcher
80374495
著者名
Shiga, Tohru
e-Rad_Researcher
60580892
著者名
Tsuchiya, Kazuhiko
著者名
Watanabe, Shiro
著者名
Takeuchi, Wataru
e-Rad_Researcher
70321958
著者名
Kuge, Yuji
著者名
Peng, Hao
e-Rad_Researcher
30171888
著者名
Tamaki, Nagara
e-Rad_Researcher
20187537
著者名
Shirato, Hiroki
言語
英語
キーワード
[18F]fluoromisonidazole
Positron emission tomography
Hypoxia
Intensity-modulated radiotherapy
Nasopharyngeal carcinoma
発行日
2017-09-06
出版者
BioMed Central
収録物名
Radiation oncology
巻(号)
12
ページ
148
抄録
Background: Hypoxic cancer cells are thought to be radioresistant and could impact local recurrence after radiotherapy (RT). One of the major hypoxic imaging modalities is [18F]fluoromisonidazole positron emission tomography (FMISO-PET). High FMISO uptake before RT could indicate radioresistant sites and might be associated with future local recurrence. The predictive value of FMISO-PET for intra-tumoral recurrence regions was evaluated using high-resolution semiconductor detectors in patients with nasopharyngeal carcinoma after intensity-modulated radiotherapy (IMRT). Methods: Nine patients with local recurrence and 12 patients without local recurrence for more than 3 years were included in this study. These patients received homogeneous and standard doses of radiation to the primary tumor irrespective of FMISO uptake. The FMISO-PET image before RT was examined via a voxel-based analysis, which focused on the relationship between the degree of FMISO uptake and recurrence region. Results: In the pretreatment FMISO-PET images, the tumor-to-muscle ratio (TMR) of FMISO in the voxels of the tumor recurrence region was significantly higher than that of the non-recurrence region (p < 0.0001). In the recurrent patient group, a TMR value of 1.37 (95% CI: 1.36-1.39) corresponded to a recurrence rate of 30%, the odds ratio was 5.18 (4.87-5.51), and the area under the curve (AUC) of the receiver operating characteristic curve was 0.613. In all 21 patients, a TMR value of 2.42 (2.36-2.49) corresponded to an estimated recurrence rate of 30%, and the AUC was only 0.591. Conclusions: The uptake of FMISO in the recurrent region was significantly higher than that in the non-recurrent region. However, the predictive value of FMISO-PET before IMRT is not sufficient for up-front dose escalation for the intra-tumoral high-uptake region of FMISO. Because of the higher mean TMR of the recurrence region, a new hypoxic imaging method is needed to improve the sensitivity and specificity for hypoxia.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution 4.0 International
PISSN
1748-717X
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1186/s13014-017-0886-9