Two Cases of Nivolumab Re-Administration after Pneumonitis as Immune-Related Adverse Events

Imafuku, Keisuke; Yoshino, Koji; Yamaguchi, Kei; Tsuboi, Satoshi; Ohara, Kuniaki; Hata, Hiroo

Two Cases of Nivolumab Re-Administration after Pneumonitis as Immune-Related Adverse Events

Imafuku, Keisuke; Yoshino, Koji; Yamaguchi, Kei et al.

Case Reports in Oncology, 2017, 10(1), 296-300

Permalink : https://hdl.handle.net/2115/67613

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アクセス権	open access
URI	https://hdl.handle.net/2115/67613
タイトル	Two Cases of Nivolumab Re-Administration after Pneumonitis as Immune-Related Adverse Events
著者	Imafuku, Keisuke ; Yoshino, Koji ; Yamaguchi, Kei ; Tsuboi, Satoshi ; Ohara, Kuniaki ; Hata, Hiroo
著者名 Imafuku, Keisuke
著者名 Yoshino, Koji
著者名 Yamaguchi, Kei
著者名 Tsuboi, Satoshi
著者名 Ohara, Kuniaki
e-Rad_Researcher 90399915 著者名 Hata, Hiroo
言語	英語
キーワード	Nivolumab
	Immune-related adverse event
	Re-administration
	Unresectable malignant melanoma
	Cryptogenic organizing pneumonia
	Diffuse alveolar damage
	Pneumonitis
発行日	2017-04
出版者	Karger
収録物名	Case Reports in Oncology
巻(号)	10(1)
ページ	296-300
抄録	Nivolumab is a recently approved medication for the treatment of unresectable malignant melanoma. Many immune-related adverse events (irAEs) associated with nivolumab have been reported, such as pneumonitis, hepatitis, dermatitis, and thyroiditis. Prednisolone can effectively treat irAEs. However, it is unclear how or if nivolumab should be administered to patients after they have experienced an irAE. Herein, we show 2 patients who underwent pneumonitis as irAE. Case 1 demonstrated a cryptogenic organizing pneumonia pattern in the CT scan and case 2 had a diffuse alveolar damage (DAD) pattern. Oral corticosteroids improved chest shadow of CT scan in both cases. However, when nivolumab was re-administrated, case 1 demonstrated no symptoms, but case 2 demonstrated pneumonia again. From our cases, it is difficult to re-administrate nivolumab for the patients with pneumonitis which shows a DAD pattern in CT, even if oral corticosteroids improve their symptoms.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial 4.0 International
権利情報	The final, published version of this article is available at http://www.karger.com/?doi=10.1159/000463379
PISSN	1662-6575
関連情報	PMID 28512413
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1159/000463379