Pathogenic analysis of the pandemic 2009 H1N1 influenza A viruses in ferrets

Tsuda, Yoshimi; Weisend, Carla; Martellaro, Cynthia et al.

Journal of veterinary medical science, 2017, 79(8), 1453-1460

Permalink : https://hdl.handle.net/2115/67631

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アクセス権
open access
URI
https://hdl.handle.net/2115/67631
タイトル
Pathogenic analysis of the pandemic 2009 H1N1 influenza A viruses in ferrets
著者
Tsuda, Yoshimi ; Weisend, Carla ; Martellaro, Cynthia ; Feldmann, Friederike ; Haddock, Elaine
著者名
Tsuda, Yoshimi
著者名
Weisend, Carla
著者名
Martellaro, Cynthia
著者名
Feldmann, Friederike
著者名
Haddock, Elaine
言語
英語
キーワード
ferret
pathogenesis
virus shedding
発行日
2017-08
出版者
The Japanese Society of Veterinary Science
収録物名
Journal of veterinary medical science
巻(号)
79(8)
ページ
1453-1460
抄録
The pandemic 2009 H1N1 influenza A virus emerged in humans and caused the first influenza pandemic of the 21st century. Mexican isolates, A/Mexico/4108/2009 (H1N1) (Mex4108) and A/Mexico/InDRE4478/2009 (H1N1) (Mex4487) derived from a mild case and from a cluster of severe cases, showed heterogeneity in virulence in a cynomolgus macaque model. To compare the more pathogenic differences, we generated recombinant viruses and compared their virulence in ferrets. Ferrets infected with recombinant Mex4487 displayed a slightly higher rate of viral replication and severe pneumonia in the early stage of infection. In contrast, prolonged lower virus shedding of recombinant Mex4108 than that of recombinant Mex4487 was detected in throat swabs. Thus, Mex4487 induces severe pneumonia in infected individuals, whereas Mex4108 might have wide-spreading potential with mild disease.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN
0916-7250
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1292/jvms.16-0619