Antibacterial and cytotoxic effects of photoexcited Au clusters via blue high-power or white low-power light emitting diode irradiation

Miyata, Saori; Miyaji, Hirofumi; Kawasaki, Hideya; Nishida, Erika; Shitomi, Kanako; Akasaka, Tsukasa; Tanaka, Saori; Iizuka, Tadashi; Sugaya, Tsutomu

Antibacterial and cytotoxic effects of photoexcited Au clusters via blue high-power or white low-power light emitting diode irradiation

Miyata, Saori; Miyaji, Hirofumi; Kawasaki, Hideya et al.

Biology, Engineering and Medicine, 2017, 2(4)

Permalink : https://hdl.handle.net/2115/67756

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アクセス権	open access
URI	https://hdl.handle.net/2115/67756
タイトル	Antibacterial and cytotoxic effects of photoexcited Au clusters via blue high-power or white low-power light emitting diode irradiation
著者	Miyata, Saori ; Miyaji, Hirofumi ; Kawasaki, Hideya ; Nishida, Erika ; Shitomi, Kanako ; Akasaka, Tsukasa ; Tanaka, Saori ; Iizuka, Tadashi ; Sugaya, Tsutomu
著者名 Miyata, Saori
e-Rad_Researcher 50372256 著者名 Miyaji, Hirofumi
著者名 Kawasaki, Hideya
著者名 Nishida, Erika
著者名 Shitomi, Kanako
e-Rad_Researcher 00360917 著者名 Akasaka, Tsukasa
e-Rad_Researcher 90344522 著者名 Tanaka, Saori
著者名 Iizuka, Tadashi
e-Rad_Researcher 10211301 著者名 Sugaya, Tsutomu
言語	英語
キーワード	Antimicrobial photodynamic therapy
	captopril-protected gold (Au) clusters
	lysozyme-stabilized gold clusters
	photosensitizer
	Streptococcus mutans
発行日	2017-10
出版者	Open Access Text
収録物名	Biology, Engineering and Medicine
巻(号)	2(4)
抄録	The development of photosensitizers and light sources has enabled the use of antimicrobial photodynamic therapy (aPDT) in various dental therapies. In the present study, we compared the antibacterial and cytotoxic effects of Au clusters photoexcited by blue and white LED irradiation. We fabricated novel photosensitizers, captopril-protected gold (Capt-Au) clusters and lysozyme-stabilized gold (Lyz-Au) clusters, for aPDT. Au clusters were then photoexcited by two kinds of light sources, blue high-power and white low-power light-emitting diodes (LEDs). Since white LED contains a wide spectrum of light (400–750 nm), white LED would be relevant for aPDT even if using a low-power source. The turbidity and viability of Streptococcus mutans were assessed following application of Capt-Au clusters (500 μg/mL) or Lyz-Au clusters (1,000 μg/mL) photoexcited by a blue high-power LED (1,000 mW/cm2) or white low-power LED (80 mW/cm2). In addition, the cytotoxicity of Au clusters and LED irradiation was evaluated in NIH3T3 and MC3T3-E1 cells. Au clusters photoexcited by the white low-power LED equally decreased the turbidity and viability of S. mutans compared with blue high-power LED. However, Au clusters photoexcited by white LED irradiation caused decreased cytotoxicity in mammalian cells compared with those photoexcited by blue LED irradiation. In conclusion, white LEDs possess biosafe properties for aPDT using Au clusters.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	2399-9632
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.15761/BEM.1000126