Satisfaction of switching to combination therapy with lixisenatide and basal insulin in patients with type 2 diabetes receiving multiple daily insulin injection therapy : A randomized controlled trial

Miya, Aika; Nakamura, Akinobu; Miyoshi, Hideaki; Cho, Kyu Yong; Nagai, So; Kurihara, Yoshio; Aoki, Shin; Taguri, Masataka; Terauchi, Yasuo; Atsumi, Tatsuya

Satisfaction of switching to combination therapy with lixisenatide and basal insulin in patients with type 2 diabetes receiving multiple daily insulin injection therapy : A randomized controlled trial

Miya, Aika; Nakamura, Akinobu; Miyoshi, Hideaki et al.

Journal of Diabetes Investigation, 2018, 9(1), 119-126

Permalink : https://hdl.handle.net/2115/68064

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アクセス権	open access
URI	https://hdl.handle.net/2115/68064
タイトル	Satisfaction of switching to combination therapy with lixisenatide and basal insulin in patients with type 2 diabetes receiving multiple daily insulin injection therapy : A randomized controlled trial
著者	Miya, Aika ; Nakamura, Akinobu ; Miyoshi, Hideaki ; Cho, Kyu Yong ; Nagai, So ; Kurihara, Yoshio ; Aoki, Shin ; Taguri, Masataka ; Terauchi, Yasuo ; Atsumi, Tatsuya
著者名 Miya, Aika
e-Rad_Researcher 70552420 著者名 Nakamura, Akinobu
e-Rad_Researcher 30360902 著者名 Miyoshi, Hideaki
著者名 Cho, Kyu Yong
e-Rad_Researcher 70507590 著者名 Nagai, So
著者名 Kurihara, Yoshio
著者名 Aoki, Shin
著者名 Taguri, Masataka
著者名 Terauchi, Yasuo
e-Rad_Researcher 20301905 著者名 Atsumi, Tatsuya
言語	英語
キーワード	Lixisenatide
	Treatment satisfaction
	Type 2 diabetes
発行日	2018-01
出版者	Wiley
収録物名	Journal of Diabetes Investigation
巻(号)	9(1)
ページ	119-126
抄録	Aims/Introduction: We compared the satisfaction levels of patients with type 2 diabetes undergoing combination therapy with lixisenatide (LIX) and basal insulin with that of patients undergoing multiple daily insulin injection (MDI) therapy. Materials and Methods: The study was a 12-week open-label, randomized, multicenter, controlled trial. Participants were Japanese patients with type 2 diabetes receiving MDI for >3 months. Patients were randomly assigned to each treatment cohort: (i) a group that continued MDI (MDI group); and (ii) a group that switched from MDI to combination therapy with LIX and basal insulin (LIX group). The primary outcome was change in Diabetes Treatment Satisfaction Questionnaire scores from baseline to 12 weeks between these two groups. Key secondary outcomes were glycated hemoglobin and body weight changes. Results: A total of 31 patients were initially enrolled in the study, and 26 of them completed the study. The change in Diabetes Treatment Satisfaction Questionnaire scores in the LIX group was significantly greater compared with that in the MDI group. Mean changes in glycated hemoglobin levels were -0.05 ± 0.37% in the MDI group and 0.04 ± 0.38% in the LIX group (P = 0.36). Mean changes in body weight were +0.6 ± 1.8 kg in the MDI group and -2.5 ± 1.8 kg in the LIX group (P < 0.01). Conclusions: Switching from MDI to combination therapy with LIX and basal insulin improved satisfaction levels while maintaining glycemic control in Japanese patients with type 2 diabetes.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial 4.0 International
PISSN	2040-1116
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1111/jdi.12654