Fibrin/fibrinogen degradation products (FDP) at hospital admission predict neurological outcomes in out-of-hospital cardiac arrest patients

Ono, Yuichi; Hayakawa, Mineji; Maekawa, Kunihiko; Kodate, Akira; Sadamoto, Yoshihiro; Tominaga, Naoki; Murakami, Hiromoto; Yoshida, Tomonao; Katabami, Kenichi; Wada, Takeshi; Sageshima, Hisako; Sawamura, Atsushi; Gando, Satoshi

Fibrin/fibrinogen degradation products (FDP) at hospital admission predict neurological outcomes in out-of-hospital cardiac arrest patients

Ono, Yuichi; Hayakawa, Mineji; Maekawa, Kunihiko et al.

Resuscitation, 2017, 111, 62-67

Permalink : https://hdl.handle.net/2115/68249

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アクセス権	open access
URI	https://hdl.handle.net/2115/68249
タイトル	Fibrin/fibrinogen degradation products (FDP) at hospital admission predict neurological outcomes in out-of-hospital cardiac arrest patients
著者	Ono, Yuichi ; Hayakawa, Mineji ; Maekawa, Kunihiko ; Kodate, Akira ; Sadamoto, Yoshihiro ; Tominaga, Naoki ; Murakami, Hiromoto ; Yoshida, Tomonao ; Katabami, Kenichi ; Wada, Takeshi ; Sageshima, Hisako ; Sawamura, Atsushi ; Gando, Satoshi
著者名 Ono, Yuichi
e-Rad_Researcher 10374282 著者名 Hayakawa, Mineji
著者名 Maekawa, Kunihiko
著者名 Kodate, Akira
著者名 Sadamoto, Yoshihiro
著者名 Tominaga, Naoki
著者名 Murakami, Hiromoto
著者名 Yoshida, Tomonao
著者名 Katabami, Kenichi
e-Rad_Researcher 30455646 著者名 Wada, Takeshi
著者名 Sageshima, Hisako
e-Rad_Researcher 00241448 著者名 Sawamura, Atsushi
e-Rad_Researcher 30125306 著者名 Gando, Satoshi
言語	英語
キーワード	Cardiopulmonary resuscitation
	Out-of-hospital cardiac arrest
	Neurological outcome
発行日	2017-02
出版者	Elsevier
収録物名	Resuscitation
巻(号)	111
ページ	62-67
抄録	Objective: This study aimed to test the hypothesis that coagulation, fibrinolytic markers and disseminated intravascular coagulation (DIC) score (International Society on Thrombosis and Haemostasis) at hospital admission of out-of-hospital cardiac arrest (OHCA) patients can predict neurological outcomes 1 month after cardiac arrest. Methods: In this retrospective, observational analysis, data were collected from the Sapporo Utstein Registry and medical records at Hokkaido University Hospital. We included patients who experienced OHCA with successful return of spontaneous circulation (ROSC) between 2006 and 2012 and were transferred to Hokkaido University Hospital. From medical records, we collected information about the following coagulation and fibrinolytic factors at hospital admission: platelet count; prothrombin time; activated partial thromboplastin time; plasma levels of fibrinogen, D-dimer, fibrin/fibrinogen degradation products (FDP), and antithrombin; and calculated DIC score. Favorable neurological outcomes were defined as a cerebral performance category 1-2. Results: We analyzed data for 315 patients. Except for fibrinogen level, all coagulation variables, fibrinolytic variables, and DIC score were associated with favorable neurological outcomes. In the receiver operating characteristic curve analysis, FDP level had the largest area under the curve (AUC; 0.795). In addition, the AUC of FDP level was larger than that of lactate level. The AUC value of FDP level might indicate that FDP is an independent predictor of favorable neurological outcomes. Conclusions: All of the coagulation and fibrinolytic markers, except for fibrinogen level, and DIC score at hospital admission, were associated with favorable neurological outcomes. Of all of the variables, FDP level was most closely associated with favorable neurological outcomes in OHCA patients who successfully achieved ROSC.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0300-9572
関連情報	PMID 27940211
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.resuscitation.2016.11.017