Expression of p53, p16, cyclin D1, epidermal growth factor receptor and Notch1 in patients with temporal bone squamous cell carcinoma

Morita, Shinya; Nakamaru, Yuji; Homma, Akihiro; Yasukawa, Shinichiro; Hatakeyama, Hiromitsu; Sakashita, Tomohiro; Kano, Satoshi; Fukuda, Atsushi; Fukuda, Satoshi

Expression of p53, p16, cyclin D1, epidermal growth factor receptor and Notch1 in patients with temporal bone squamous cell carcinoma

Morita, Shinya; Nakamaru, Yuji; Homma, Akihiro et al.

International Journal of Clinical Oncology, 2017, 22(1), 181-189

Permalink : https://hdl.handle.net/2115/68250

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アクセス権	open access
URI	https://hdl.handle.net/2115/68250
タイトル	Expression of p53, p16, cyclin D1, epidermal growth factor receptor and Notch1 in patients with temporal bone squamous cell carcinoma
その他のタイトル	Expression of p53, p16, cyclin D1, EGFR and Notch1 in patients with the temporal bone squamous cell carcinoma
著者	Morita, Shinya ; Nakamaru, Yuji ; Homma, Akihiro ; Yasukawa, Shinichiro ; Hatakeyama, Hiromitsu ; Sakashita, Tomohiro ; Kano, Satoshi ; Fukuda, Atsushi ; Fukuda, Satoshi
著者名 Morita, Shinya
e-Rad_Researcher 20344509 著者名 Nakamaru, Yuji
e-Rad_Researcher 30312359 著者名 Homma, Akihiro
著者名 Yasukawa, Shinichiro
e-Rad_Researcher 10455652 著者名 Hatakeyama, Hiromitsu
e-Rad_Researcher 30455654 著者名 Sakashita, Tomohiro
e-Rad_Researcher 00374421 著者名 Kano, Satoshi
著者名 Fukuda, Atsushi
e-Rad_Researcher 20125347 著者名 Fukuda, Satoshi
言語	英語
キーワード	Temporal bone squamous cell carcinoma
	Clinicopathological features
	EGFR
	Protein expression
	Immunohistochemistry
	Prognostic factor
発行日	2017-02
出版者	Springer
収録物名	International Journal of Clinical Oncology
巻(号)	22(1)
ページ	181-189
抄録	Background: The aim of this study was to investigate the expression of p53, p16, cyclin D1, epidermal growth factor receptor (EGFR) and Notch1 in temporal bone squamous cell carcinoma (TBSCC) tissue samples by immunohistochemistry (IHC), and to evaluate the association between these biomarkers and clinicopathological features. Methods: We performed a retrospective, single-institution review of 30 TBSCC patients treated with curative intent between April 2006 and March 2015. All tissue samples were obtained from pretreatment biopsy specimens or surgical specimens and using IHC staining. Results: Ten patients were categorized as T1, seven as T2, five as T3 and eight as T4. Nine patients had clinically positive lymph node metastasis. The positive expression of p53 and EGFR was significantly associated with T classification (P = 0.042 and P = 0.0039). EGFR expression was significantly more frequent in patients with positive lymph node metastasis compared with patients without node involvement (P = 0.017). In the analysis of the association between protein expression by IHC staining and prognosis, the positive expression of EGFR and Notch1 was significantly correlated with poor survival outcomes in TBSCC (P = 0.015 and P = 0.025) Conclusion: Overexpression of p53 and EGFR may be valuable biomarkers for identifying individuals at high risk of developing tumors in TBSCC. Furthermore, the positive expression of EGFR was significantly associated with poor survival outcome. Anti-EGFR therapy has potential for use as the treatment modality of choice for advanced-stage TBSCC as well as other head and neck squamous cell carcinomas.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The final publication is available at Springer via http://dx.doi.org/10.1007/s10147-016-1026-5
PISSN	1341-9625
関連情報	PMID 27488595
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s10147-016-1026-5