Pretreatment lymphocyte-to-monocyte ratio as an independent prognostic factor for head and neck cancer

Kano, Satoshi; Homma, Akihiro; Hatakeyama, Hiromitsu; Mizumachi, Takatsugu; Sakashita, Tomohiro; Kakizaki, Tomohiko; Fukuda, Satoshi

Pretreatment lymphocyte-to-monocyte ratio as an independent prognostic factor for head and neck cancer

Kano, Satoshi; Homma, Akihiro; Hatakeyama, Hiromitsu et al.

Head & neck, 2017, 39(2), 247-253

Permalink : https://hdl.handle.net/2115/68256

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アクセス権	open access
URI	https://hdl.handle.net/2115/68256
タイトル	Pretreatment lymphocyte-to-monocyte ratio as an independent prognostic factor for head and neck cancer
著者	Kano, Satoshi ; Homma, Akihiro ; Hatakeyama, Hiromitsu ; Mizumachi, Takatsugu ; Sakashita, Tomohiro ; Kakizaki, Tomohiko ; Fukuda, Satoshi
e-Rad_Researcher 00374421 著者名 Kano, Satoshi
e-Rad_Researcher 30312359 著者名 Homma, Akihiro
e-Rad_Researcher 10455652 著者名 Hatakeyama, Hiromitsu
e-Rad_Researcher 00507577 著者名 Mizumachi, Takatsugu
e-Rad_Researcher 30455654 著者名 Sakashita, Tomohiro
著者名 Kakizaki, Tomohiko
e-Rad_Researcher 20125347 著者名 Fukuda, Satoshi
言語	英語
キーワード	neutrophil-to-lymphocyte ratio (NLR)
	platelet-to-lymphocyte ratio (PLR)
	lymphocyte-to-monocyte ratio (LMR)
	head and neck cancer
	chemoradiotherapy
発行日	2017-02
出版者	Wiley
収録物名	Head & neck
巻(号)	39(2)
ページ	247-253
抄録	Background: The purpose of this study was to analyze the relationship between pretreatment inflammatory markers and the prognosis of patients with oropharyngeal, hypopharyngeal, and laryngeal cancers. Methods: The data for 285 patients treated with curative intent by concurrent chemoradiotherapy (CRT) were obtained and their pretreatment inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) were calculated. Results: Significant relationships were observed between a high NLR and oropharyngeal or hypopharyngeal cancer, T3 to T4, N2b to N3, and clinical stage III to IV, whereas significant relationships were observed between a high LMR and laryngeal cancer, T1 to T2, and clinical stage I to II. With regard to survival outcomes, a high NLR, a high PLR, and a low LMR were all significantly associated with decreases in overall survival OS) and disease-free survival (DFS). Furthermore, multivariate analysis showed that LMR was an independent prognostic factor. Conclusion: Pretreatment LMR was found to be an independent prognostic factor for patients with head and neck cancers treated by concurrent CRT.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is the peer reviewed version of the following article: Kano, S., Homma, A., Hatakeyama, H., Mizumachi, T., Sakashita, T., Kakizaki, T. and Fukuda, S. (2017), Pretreatment lymphocyte-to-monocyte ratio as an independent prognostic factor for head and neck cancer. Head Neck, 39: 247–253, which has been published in final form at http://dx.doi.org/10.1002/hed.24576. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
PISSN	1043-3074
関連情報	PMID 27617428
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1002/hed.24576