Characterization of a Novel Bat Adenovirus Isolated from Straw-Colored Fruit Bat (Eidolon helvum)

Ogawa, Hirohito; Kajihara, Masahiro; Nao, Naganori; Shigeno, Asako; Fujikura, Daisuke; Hang'ombe, Bernard M.; Mweene, Aaron S.; Mutemwa, Alisheke; Squarre, David; Yamada, Masao; Higashi, Hideaki; Sawa, Hirofumi; Takada, Ayato

Characterization of a Novel Bat Adenovirus Isolated from Straw-Colored Fruit Bat (Eidolon helvum)

Ogawa, Hirohito; Kajihara, Masahiro; Nao, Naganori et al.

Viruses, 2017, 9(12), 371

Permalink : https://hdl.handle.net/2115/68273

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アクセス権	open access
URI	https://hdl.handle.net/2115/68273
タイトル	Characterization of a Novel Bat Adenovirus Isolated from Straw-Colored Fruit Bat (Eidolon helvum)
著者	Ogawa, Hirohito ; Kajihara, Masahiro ; Nao, Naganori ; Shigeno, Asako ; Fujikura, Daisuke ; Hang'ombe, Bernard M. ; Mweene, Aaron S. ; Mutemwa, Alisheke ; Squarre, David ; Yamada, Masao ; Higashi, Hideaki ; Sawa, Hirofumi ; Takada, Ayato
著者名 Ogawa, Hirohito
著者名 Kajihara, Masahiro
著者名 Nao, Naganori
著者名 Shigeno, Asako
e-Rad_Researcher 70547794 著者名 Fujikura, Daisuke
著者名 Hang'ombe, Bernard M.
著者名 Mweene, Aaron S.
著者名 Mutemwa, Alisheke
著者名 Squarre, David
著者名 Yamada, Masao
e-Rad_Researcher 20311227 著者名 Higashi, Hideaki
e-Rad_Researcher 30292006 著者名 Sawa, Hirofumi
e-Rad_Researcher 10292062 著者名 Takada, Ayato
言語	英語
キーワード	adenovirus
	bat
	Eidolon helvum
	Zambia
発行日	2017-12
出版者	MDPI
収録物名	Viruses
巻(号)	9(12)
ページ	371
抄録	Bats are important reservoirs for emerging zoonotic viruses. For extensive surveys of potential pathogens in straw-colored fruit bats (Eidolon helvum) in Zambia, a total of 107 spleen samples of E. helvum in 2006 were inoculated onto Vero E6 cells. The cell culture inoculated with one of the samples (ZFB06-106) exhibited remarkable cytopathic changes. Based on the ultrastructural property in negative staining and cross-reactivity in immunofluorescence assays, the virus was suspected to be an adenovirus, and tentatively named E. helvum adenovirus 06-106 (EhAdV 06-106). Analysis of the full-length genome of 30,134 bp, determined by next-generation sequencing, showed the presence of 28 open reading frames. Phylogenetic analyses confirmed that EhAdV 06-106 represented a novel bat adenovirus species in the genus Mastadenovirus. The virus shared similar characteristics of low G + C contents with recently isolated members of species Bat mastadenoviruses E, F and G, from which EhAdV 06-106 diverged by more than 15% based on the distance matrix analysis of DNA polymerase amino acid sequences. According to the taxonomic criteria, we propose the tentative new species name “Bat mastadenovirus H”. Because EhAdV 06-106 exhibited a wide in vitro cell tropism, the virus might have a potential risk as an emerging virus through cross-species transmission.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1999-4915
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/v9120371