R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease

Hayase, Eiko; Hashimoto, Daigo; Nakamura, Kiminori; Noizat, Clara; Ogasawara, Reiki; Takahashi, Shuichiro; Ohigashi, Hiroyuki; Yokoi, Yuki; Sugimoto, Rina; Matsuoka, Satomi; Ara, Takahide; Yokoyama, Emi; Yamakawa, Tomohiro; Ebata, Ko; Kondo, Takeshi; Hiramine, Rina; Aizawa, Tomoyasu; Ogura, Yoshitoshi; Hayashi, Tetsuya; Mori, Hiroshi; Kurokawa, Ken; Tomizuka, Kazuma; Ayabe, Tokiyoshi; Teshima, Takanori

R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease

Hayase, Eiko; Hashimoto, Daigo; Nakamura, Kiminori et al.

Journal of experimental medicine, 2017, 214(12), 3507-3518

Permalink : https://hdl.handle.net/2115/68336

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アクセス権	open access
URI	https://hdl.handle.net/2115/68336
タイトル	R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease
著者	Hayase, Eiko ; Hashimoto, Daigo ; Nakamura, Kiminori ; Noizat, Clara ; Ogasawara, Reiki ; Takahashi, Shuichiro ; Ohigashi, Hiroyuki ; Yokoi, Yuki ; Sugimoto, Rina ; Matsuoka, Satomi ; Ara, Takahide ; Yokoyama, Emi ; Yamakawa, Tomohiro ; Ebata, Ko ; Kondo, Takeshi ; Hiramine, Rina ; Aizawa, Tomoyasu ; Ogura, Yoshitoshi ; Hayashi, Tetsuya ; Mori, Hiroshi ; Kurokawa, Ken ; Tomizuka, Kazuma ; Ayabe, Tokiyoshi ; Teshima, Takanori
著者名 Hayase, Eiko
e-Rad_Researcher 20419576 著者名 Hashimoto, Daigo
e-Rad_Researcher 80381276 著者名 Nakamura, Kiminori
著者名 Noizat, Clara
著者名 Ogasawara, Reiki
著者名 Takahashi, Shuichiro
著者名 Ohigashi, Hiroyuki
著者名 Yokoi, Yuki
著者名 Sugimoto, Rina
著者名 Matsuoka, Satomi
著者名 Ara, Takahide
著者名 Yokoyama, Emi
著者名 Yamakawa, Tomohiro
著者名 Ebata, Ko
e-Rad_Researcher 70333606 著者名 Kondo, Takeshi
著者名 Hiramine, Rina
e-Rad_Researcher 40333596 著者名 Aizawa, Tomoyasu
著者名 Ogura, Yoshitoshi
著者名 Hayashi, Tetsuya
著者名 Mori, Hiroshi
著者名 Kurokawa, Ken
著者名 Tomizuka, Kazuma
e-Rad_Researcher 90301019 著者名 Ayabe, Tokiyoshi
e-Rad_Researcher 40284096 著者名 Teshima, Takanori
言語	英語
発行日	2017-12-04
出版者	Rockefeller University Press
収録物名	Journal of experimental medicine
巻(号)	214(12)
ページ	3507-3518
抄録	The intestinal microbial ecosystem is actively regulated by Paneth cell-derived antimicrobial peptides such as α-defensins. Various disorders, including graft-versus-host disease (GVHD), disrupt Paneth cell functions, resulting in unfavorably altered intestinal microbiota (dysbiosis), which further accelerates the underlying diseases. Current strategies to restore the gut ecosystem are bacteriotherapy such as fecal microbiota transplantation and probiotics, and no physiological approach has been developed so far. In this study, we demonstrate a novel approach to restore gut microbial ecology by Wnt agonist R-Spondin1 (R-Spo1) or recombinant α-defensin in mice. R-Spo1 stimulates intestinal stem cells to differentiate to Paneth cells and enhances luminal secretion of α-defensins. Administration of R-Spo1 or recombinant α-defensin prevents GVHD-mediated dysbiosis, thus representing a novel and physiological approach at modifying the gut ecosystem to restore intestinal homeostasis and host-microbiota cross talk toward therapeutic benefits.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International
権利情報	©Eiko Hayase, et al., 2017. Originally published in Journal of Experimental Medicine. https://doi.org/10.1084/jem.20170418
PISSN	0022-1007
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1084/jem.20170418