Expression and Potential Role of GATA Factors in Trophoblast Development

BAI, Hanako; SAKURAI, Toshihiro; GODKIN, James D. et al.

Journal of Reproduction and Development, 2013, 59(1), 1-6

Permalink : https://hdl.handle.net/2115/68349

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アクセス権
open access
URI
https://hdl.handle.net/2115/68349
タイトル
Expression and Potential Role of GATA Factors in Trophoblast Development
著者
BAI, Hanako ; SAKURAI, Toshihiro ; GODKIN, James D. ; IMAKAWA, Kazuhiko
著者名
BAI, Hanako
著者名
SAKURAI, Toshihiro
著者名
GODKIN, James D.
著者名
IMAKAWA, Kazuhiko
言語
英語
キーワード
Development
GATA factors
Mammals
Transcriptional regulation
Trophectoderm (TE)
発行日
2013
出版者
日本繁殖生物学会
収録物名
Journal of Reproduction and Development
巻(号)
59(1)
ページ
1-6
抄録
Despite exhaustive studies, molecular mechanisms governing blastocyst formation, implantation to the uterine endometrium and placentation have not been definitively characterized. GATA family proteins are a group of zinc finger transcription factors, for which gene ablations eventually result in embryonic death later in pregnancy. These findings suggested that GATA factors are not essential for early embryonic development. However, recent studies from our laboratory and others have revealed that GATA proteins are involved in the regulation of key genes expressed by the trophectoderm that underpin the transition from the morula to trophoblast, and trophectoderm maintenance. Consequently, it is important to consider the current understanding how GATA factors govern early trophectoderm development.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報
©2013 by the Society for Reproduction and Development
PISSN
0916-8818
EISSN
1348-4400
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1262/jrd.2012-100