open access

https://hdl.handle.net/2115/68350

Research and issues for pregnancy improvements during the peri-implantation period in ruminants

日本語

pregnancy

2013

日本畜産学会

日本畜産学会報

84(3)

301-308

Even after successful fertilization in the mammalian species, nearly 50% of pregnancies fail, 70∼80% of which are lost during the peri-implantation period. It is thought that early embryonic loss results from a lack or shortage of pregnancy recognition. In ruminants, interferon tau (IFNT), an anti-luteolytic substance produced by the embryonic trophectoderm, is a major signal for the maternal recognition of pregnancy. For over 10 years, we have been studying molecular mechanisms associated with IFNT gene transcription for its effective regulation, resulting in the identification many regulatory factors. In addition, intrauterine administration of IFNT has been performed for the means to improve pregnancy rate. However, no effective therapy with IFNT is yet known to exist. For these reasons, future research needs to be directed toward the identification of what conditions that allows the conceptus to express IFNT as well as other factors properly in vivo. More importantly, these findings should be placed into the practical use in which the treatment developed actually improves pregnancy rates.

学術雑誌論文

Version of Record

© 2013 Japanese Society of Animal Science

1346-907X

1880-8255