open access

https://hdl.handle.net/2115/68398

Frequency of malformed infants in a tertiary center in Hokkaido, Japan over a period of 10 years

Malformed newborns in a tertiary center

英語

tertiary center

2017-03

Wiley

Journal of Obstetrics and Gynaecology Research

43(3)

505-510

Aim: This retrospective study was performed to determine the frequency of malformed infants born at a tertiary center in Hokkaido, Japan. The accuracy of prenatal diagnosis rates was also investigated. Methods: An observational study was performed using data of 1509 and 1743 newborn infants at a single center during two study periods, 2005-2009 (first) and 2010-2014 (second), respectively. Cases including minor anomalies (accessory auricle, nevus and fistula auris congenita) were not included. Results: In total, 274 and 569 malformations were identified in 191 and 337 newborn infants in the first and second study periods, respectively. The number of malformed infants increased significantly over time (13% [191/1509] vs 19% [337/1743], respectively; P < 0.001), mainly as a result of an increase in cases of congenital heart disease (CHD), from 59 to 141 (31% [59/191] vs 42% [141/337] of all malformed infants in the first and second periods, respectively). The overall accurate prenatal diagnosis rate improved over time from 47% (128/274) to 58% (329/569) because of significant improvements in accurate prenatal diagnosis of CHD subtypes (23% [16/70] vs 65% [151/232] in the first and second periods, respectively, P < 0.0001). Conclusions: The frequency of malformed newborns was higher in the tertiary center than in the general population. The increased number of cases with prenatal suspicion and diagnosis of CHD contributed to the increased frequency of malformed infants during the study period.

学術雑誌論文

Accepted Manuscript

This is the peer reviewed version of the following article: Hayasaka, I., Cho, K., Uzuki, Y., Morioka, K., Akimoto, T., Ishikawa, S., Takei, K., Yamada, T., Morikawa, M., Yamada, T., Ariga, T., and Minakami, H. (2017) Frequency of malformed infants in a tertiary center in Hokkaido, Japan over a period of 10 years. J. Obstet. Gynaecol. Res., 43: 505–510, which has been published in final form at http://dx.doi.org/10.1111/jog.13229. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

1341-8076