Prediction of the treatment outcome using intravoxel incoherent motion and diffusional kurtosis imaging in nasal or sinonasal squamous cell carcinoma patients

Fujima, Noriyuki; Yoshida, Daisuke; Sakashita, Tomohiro; Homma, Akihiro; Tsukahara, Akiko; Shimizu, Yukie; Tha, Khin Khin; Kudo, Kohsuke; Shirato, Hiroki

Prediction of the treatment outcome using intravoxel incoherent motion and diffusional kurtosis imaging in nasal or sinonasal squamous cell carcinoma patients

Fujima, Noriyuki; Yoshida, Daisuke; Sakashita, Tomohiro et al.

European radiology, 2017, 27(3), 956-965

Permalink : https://hdl.handle.net/2115/68399

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アクセス権	open access
URI	https://hdl.handle.net/2115/68399
タイトル	Prediction of the treatment outcome using intravoxel incoherent motion and diffusional kurtosis imaging in nasal or sinonasal squamous cell carcinoma patients
著者	Fujima, Noriyuki ; Yoshida, Daisuke ; Sakashita, Tomohiro ; Homma, Akihiro ; Tsukahara, Akiko ; Shimizu, Yukie ; Tha, Khin Khin ; Kudo, Kohsuke ; Shirato, Hiroki
e-Rad_Researcher 80431360 著者名 Fujima, Noriyuki
著者名 Yoshida, Daisuke
e-Rad_Researcher 30455654 著者名 Sakashita, Tomohiro
e-Rad_Researcher 30312359 著者名 Homma, Akihiro
著者名 Tsukahara, Akiko
著者名 Shimizu, Yukie
e-Rad_Researcher 20451445 著者名 Tha, Khin Khin
e-Rad_Researcher 10374232 著者名 Kudo, Kohsuke
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
言語	英語
キーワード	Magnetic resonance imaging
	Squamous cell carcinoma of the head and neck
	Diffusion magnetic resonance imaging
	Prognosis
	Treatment outcome
発行日	2017-03
出版者	Springer
収録物名	European radiology
巻(号)	27(3)
ページ	956-965
抄録	Objectives: To evaluate the diagnostic value of intravoxel incoherent motion (IVIM) and diffusional kurtosis imaging (DKI) parameters in nasal or sinonasal squamous cell carcinoma (SCC) patients to determine local control/failure. Methods: Twenty-eight patients were evaluated. MR acquisition used single-shot spin-echo EPI with 12 b-values. Quantitative parameters (mean value, 25th, 50th and 75th percentiles) of IVIM (perfusion fraction f, pseudo-diffusion coefficient D*, and true-diffusion coefficient D), DKI (kurtosis value K, kurtosis corrected diffusion coefficient Dk) and apparent diffusion coefficient (ADC) were calculated. Parameter values at both the pretreatment and early-treatment period, and the percentage change between these two periods were obtained. Results: Multivariate logistic regression analysis: the percentage changes of D (mean, 25th, 50th, 75th), K (mean, 50th, 75th), Dk (mean, 25th, 50th), and ADC (mean, 25th, 50th) were predictors of local control. ROC curve analysis: the parameter with the highest accuracy = the percentage change of D value with the histogram 25th percentile (0.93 diagnostic accuracy). Multivariate Cox regression analyses: the percentage changes of D (mean, 25th, 50th), K (mean, 50th, 75th), Dk (mean, 25th, 50th) and ADC (mean, 25th, 50th) are predictors. Conclusions: IVIM and DKI parameters, especially the D-value's histogram 25th percentile, are useful for predicting local control.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The original publication is available at www.springerlink.com
PISSN	0938-7994
関連情報	PMID 27255401
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00330-016-4440-1