Urine Levels of Defensin α1 Reflect Kidney Injury in Leptospirosis Patients

Chagan-Yasutan, Haorile; Chen, Yue; Lacuesta, Talitha Lea; Leano, Prisca Susan A.; Iwasaki, Hiroko; Hanan, Firmanto; Taurustiati, Delsi; Ohmoto, Yasukazu; Ashino, Yugo; Saitoh, Hiroki; Kiyomoto, Hideyasu; Suzuki, Yasuhiko; Telan, Freda O. Elizabeth; Hattori, Toshio

Urine Levels of Defensin α1 Reflect Kidney Injury in Leptospirosis Patients

Chagan-Yasutan, Haorile; Chen, Yue; Lacuesta, Talitha Lea et al.

International Journal of Molecular Sciences, 2016, 17(10), 1637

Permalink : https://hdl.handle.net/2115/68482

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アクセス権	open access
URI	https://hdl.handle.net/2115/68482
タイトル	Urine Levels of Defensin α1 Reflect Kidney Injury in Leptospirosis Patients
著者	Chagan-Yasutan, Haorile ; Chen, Yue ; Lacuesta, Talitha Lea ; Leano, Prisca Susan A. ; Iwasaki, Hiroko ; Hanan, Firmanto ; Taurustiati, Delsi ; Ohmoto, Yasukazu ; Ashino, Yugo ; Saitoh, Hiroki ; Kiyomoto, Hideyasu ; Suzuki, Yasuhiko ; Telan, Freda O. Elizabeth ; Hattori, Toshio
著者名 Chagan-Yasutan, Haorile
著者名 Chen, Yue
著者名 Lacuesta, Talitha Lea
著者名 Leano, Prisca Susan A.
著者名 Iwasaki, Hiroko
著者名 Hanan, Firmanto
著者名 Taurustiati, Delsi
著者名 Ohmoto, Yasukazu
著者名 Ashino, Yugo
著者名 Saitoh, Hiroki
著者名 Kiyomoto, Hideyasu
e-Rad_Researcher 90206540 著者名 Suzuki, Yasuhiko
著者名 Telan, Freda O. Elizabeth
著者名 Hattori, Toshio
言語	英語
キーワード	leptospirosis
	defensin α1
	neutrophil gelatinase-associated lipocalin (NGAL)
	kidney injury
	N-acetyl-β -D-glucosidase (NAG)
発行日	2016-09-27
出版者	MDPI
収録物名	International Journal of Molecular Sciences
巻(号)	17(10)
ページ	1637
抄録	Leptospirosis is a zoonotic disease whose severe forms are often accompanied by kidney dysfunction. In the present study, urinary markers were studied for potential prediction of disease severity. Urine samples from 135 patients with or without leptospirosis at San Lazaro Hospital, the Philippines, were analyzed. Urine levels of defensin 1 (uDA1) were compared with those of neutrophil gelatinase-associated lipocalin (uNGAL) and N-acetyl- -D-glucosidase (uNAG). Serum creatinine (Cr) was used as a marker of kidney injury. The levels of uDA1/Cr, uNGAL/Cr, and uNAG/Cr were positive in 46%, 90%, and 80% of leptospirosis patients, and 69%, 70%, and 70% of non-leptospirosis patients, respectively. In leptospirosis patients, the correlation of uDA1/Cr, uNGAL/Cr and uNAG/Cr levels with serum Cr were r = 0.3 (p < 0.01), r = 0.29 (p < 0.01), and r = 0.02 (p = 0.81), respectively. uDA1/Cr levels were correlated with uNGAL/Cr levels (r = 0.49, p < 0.01) and uNAG/Cr levels (r = 0.47, p < 0.0001) in leptospirosis patients. These findings suggest that uDA1, uNGAL, and uNAG were elevated in leptospirosis patients and reflected various types of kidney damage. uDA1 and uNGAL can be used to track kidney injury in leptospirosis patients because of their correlation with the serum Cr level.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	1422-0067
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/ijms17101637