Fructose suppresses uric acid excretion to the intestinal lumen as a result of the induction of oxidative stress by NADPH oxidase activation

Kaneko, Chihiro; Ogura, Jiro; Sasaki, Shunichi; Okamoto, Keisuke; Kobayashi, Masaki; Kuwayama, Kaori; Narumi, Katsuya; Iseki, Ken

Fructose suppresses uric acid excretion to the intestinal lumen as a result of the induction of oxidative stress by NADPH oxidase activation

Kaneko, Chihiro; Ogura, Jiro; Sasaki, Shunichi et al.

Biochimica et Biophysica Acta (BBA) General subjects, 2017, 1861(3), 559-566

Permalink : https://hdl.handle.net/2115/68654

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アクセス権	open access
URI	https://hdl.handle.net/2115/68654
タイトル	Fructose suppresses uric acid excretion to the intestinal lumen as a result of the induction of oxidative stress by NADPH oxidase activation
著者	Kaneko, Chihiro ; Ogura, Jiro ; Sasaki, Shunichi ; Okamoto, Keisuke ; Kobayashi, Masaki ; Kuwayama, Kaori ; Narumi, Katsuya ; Iseki, Ken
著者名 Kaneko, Chihiro
著者名 Ogura, Jiro
著者名 Sasaki, Shunichi
著者名 Okamoto, Keisuke
e-Rad_Researcher 70431319 著者名 Kobayashi, Masaki
著者名 Kuwayama, Kaori
著者名 Narumi, Katsuya
e-Rad_Researcher 40203062 著者名 Iseki, Ken
言語	英語
キーワード	Hyperuricemia
	Fructose
	Uric acid excretion
	Breast cancer resistance protein
	Oxidative stress
	NADPH oxidase
発行日	2017-03
出版者	Elsevier
収録物名	Biochimica et Biophysica Acta (BBA) General subjects
巻(号)	1861(3)
ページ	559-566
抄録	Background: A high intake of fructose increases the risk for hyperuricemia. It has been reported that long-term fructose consumption suppressed renal uric acid excretion and increased serum uric acid level. However, the effect of single administration of fructose on excretion of uric acid has not been clarified. Methods: We used male Wistar rats, which were orally administered fructose (5 g/kg). Those rats were used in each experiment at 12 h after administration. Results: Single administration of fructose suppressed the function of ileal uric acid excretion and had no effect on the function of renal uric acid excretion. Breast cancer resistance protein (BCRP) predominantly contributes to intestinal excretion of uric acid as an active homodimer. Single administration of fructose decreased BCRP homodimer level in the ileum. Moreover, diphenyleneiodonium (DPI), an inhibitor of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox), recovered the suppression of the function of ileal uric acid excretion and the Bcrp homodimer level in the ileum of rats that received single administration of fructose. Conclusions: Single administration of fructose decreases in BCRP homodimer level, resulting in the suppression the function of ileal uric acid excretion. The suppression of the function of ileal uric acid excretion by single administration of fructose is caused by the activation of Nox. The results of our study provide a new insight into the mechanism of fructose-induced hyperuricemia. (C) 2016 Elsevier B.V. All rights reserved.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0304-4165
関連情報	PMID 27913188
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.bbagen.2016.11.042