Blood soluble Fas levels and mortality from cardiovascular disease in middle-aged Japanese : The JACC study

Iso, Hiroyasu; Maruyama, Koutatsu; Eshak, Ehab S.; Ikehara, Satoyo; Yamagishi, Kazumasa; Tamakoshi, Akiko

Blood soluble Fas levels and mortality from cardiovascular disease in middle-aged Japanese : The JACC study

Iso, Hiroyasu; Maruyama, Koutatsu; Eshak, Ehab S. et al.

Atherosclerosis, 2017, 260, 97-101

Permalink : https://hdl.handle.net/2115/70044

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アクセス権	open access
URI	https://hdl.handle.net/2115/70044
タイトル	Blood soluble Fas levels and mortality from cardiovascular disease in middle-aged Japanese : The JACC study
著者	Iso, Hiroyasu ; Maruyama, Koutatsu ; Eshak, Ehab S. ; Ikehara, Satoyo ; Yamagishi, Kazumasa ; Tamakoshi, Akiko
e-Rad_Researcher 50223053 著者名 Iso, Hiroyasu
著者名 Maruyama, Koutatsu
著者名 Eshak, Ehab S.
著者名 Ikehara, Satoyo
著者名 Yamagishi, Kazumasa
e-Rad_Researcher 90236737 著者名 Tamakoshi, Akiko
言語	英語
キーワード	Biomarkers
	Stroke
	Subarachnoid hemorrhage
	Coronary heart disease
	Mortality
	Nested-case control study
発行日	2017-05
出版者	Elsevier
収録物名	Atherosclerosis
巻(号)	260
ページ	97-101
抄録	Background and aims: Limited evidence has been available on the relationship between apoptosis and cardiovascular disease in population-based samples. We examined whether blood soluble Fas (sFas) are associated with mortality from cardiovascular diseases. Methods: In a nested case-control study under a large prospective cohort, the Japan Collaborative Cohort (JACC) Study, where a total of 39,242 subjects, 40-79 years of age, provided serum samples and were followed up for 9 years, we measured sFas levels among cases and controls, matched for sex, age, area of residence and year of serum storage. Conditional logistic regression models were used to calculate odds ratio (95% CI) of mortality from stroke and stroke types, according to quartiles and 1-SD increment of sFas levels. Results: During the follow-up (1988-1997), we identified 233 (121 in men and 112 in women) deaths from total stroke, comprising 49 (18 and 31) subarachnoid hemorrhages, 55 (27 and 28) intra-parenchymal hemorrhages, 71 (44 and 27) ischemic strokes, and 97 (53 and 44) coronary heart diseases. After adjustment for cardiovascular risk factors, the multivariable odds ratio (95% CI) of subarachnoid hemorrhage associated with a 1-SD increment of sFas (1.3 ng/ml in both men and women) was 4.04 (1.07-15.3; p = 0.04). No association was found between blood sFas levels and risk of intraparenchymal hemorrhage, ischemic stroke or coronary heart disease. Conclusions: Higher blood sFas levels were associated with higher mortality from subarachnoid hemorrhage, suggesting a potential role of apoptosis factors in the development or prognosis of subarachnoid hemorrhage.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0021-9150
関連情報	PMID 28371684
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.atherosclerosis.2017.03.020