Post-relapse survival in patients with the early and late distant recurrence in estrogen receptor-positive HER2-negative breast cancer

Ogiya, Akiko; Yamazaki, Kieko; Horii, Rie; Shien, Tadahiko; Horimoto, Yoshiya; Masuda, Norikazu; Inao, Touko; Hosoda, Mitsuchika; Ishida, Naoko; Osako, Tomofumi; Takahashi, Masato; Endo, Yumi; Miyoshi, Yuichiro; Yasojima, Hiroyuki; Tomioka, Nobumoto; Yamashita, Hiroko; Collaborative Study Group of Scientific Research of the Japanese Breast Cancer Society

Post-relapse survival in patients with the early and late distant recurrence in estrogen receptor-positive HER2-negative breast cancer

Ogiya, Akiko; Yamazaki, Kieko; Horii, Rie et al.

Breast cancer, 2017, 24(3), 473-482

Permalink : https://hdl.handle.net/2115/70047

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アクセス権	open access
URI	https://hdl.handle.net/2115/70047
タイトル	Post-relapse survival in patients with the early and late distant recurrence in estrogen receptor-positive HER2-negative breast cancer
著者	Ogiya, Akiko ; Yamazaki, Kieko ; Horii, Rie ; Shien, Tadahiko ; Horimoto, Yoshiya ; Masuda, Norikazu ; Inao, Touko ; Hosoda, Mitsuchika ; Ishida, Naoko ; Osako, Tomofumi ; Takahashi, Masato ; Endo, Yumi ; Miyoshi, Yuichiro ; Yasojima, Hiroyuki ; Tomioka, Nobumoto ; Yamashita, Hiroko ; Collaborative Study Group of Scientific Research of the Japanese Breast Cancer Society
著者名 Ogiya, Akiko
著者名 Yamazaki, Kieko
e-Rad_Researcher 20446272 著者名 Horii, Rie
e-Rad_Researcher 30509451 著者名 Shien, Tadahiko
著者名 Horimoto, Yoshiya
著者名 Masuda, Norikazu
著者名 Inao, Touko
e-Rad_Researcher 40443931 著者名 Hosoda, Mitsuchika
著者名 Ishida, Naoko
著者名 Osako, Tomofumi
著者名 Takahashi, Masato
e-Rad_Researcher 20566228 著者名 Endo, Yumi
著者名 Miyoshi, Yuichiro
著者名 Yasojima, Hiroyuki
著者名 Tomioka, Nobumoto
e-Rad_Researcher 70332947 著者名 Yamashita, Hiroko
著者名 Collaborative Study Group of Scientific Research of the Japanese Breast Cancer Society
言語	英語
キーワード	Breast cancer
	Post-relapse survival
	Prognosis
	Estrogen receptor-positive
	Endocrine therapy
発行日	2017-05
出版者	Springer
収録物名	Breast cancer
巻(号)	24(3)
ページ	473-482
抄録	Background: Few studies have been performed on post-relapse survival in patients with the early and late distant recurrence in estrogen receptor (ER)-positive, HER2-negative breast cancer. Methods: A total of 205 patients with the early distant recurrence and 134 patients with the late distant recurrence of ER-positive, HER2-negative breast cancer who had undergone breast surgery or neoadjuvant chemotherapy between January 2000 and December 2004 were registered from nine institutions. Prognostic factors for post-relapse survival in patients with the early and late recurrence were analyzed. Results: Post-relapse survival was significantly longer in patients with the late recurrence than in patients with the early recurrence. Predictive factors for post-relapse survival in patients with the early recurrence were lack of adjuvant chemotherapy, a long disease-free interval, and long durations of endocrine therapies and chemotherapies after relapse. In patients with the late recurrence, post-relapse survival was significantly improved for those individuals with one metastatic organ at relapse and individuals who were treated with the first-line and subsequent endocrine therapies for prolonged periods. Moreover, ER expression in primary breast tumors of late recurrence patients was significantly higher with a duration of the first-line endocrine therapy >6 months than in those with a duration ≤6 months. Conclusion: Predictors for prognosis after relapse differed between patients with the early and late distant recurrence. Endocrine responsiveness after relapse is a key factor for improved post-relapse survival, and it is thus important to establish whether metastatic tumors are endocrine-resistant in ER-positive, HER2-negative recurrent breast cancer.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The final publication is available at link.springer.com
PISSN	1340-6868
関連情報	PMID 27628678
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s12282-016-0730-3