The effect of duration of illness and antipsychotics on subcortical volumes in schizophrenia : Analysis of 778 subjects

Hashimoto, Naoki; Ito, Yoichi M.; Okada, Naohiro et al.

NeuroImage : Clinical, 2018, 17, 563-569

Permalink : https://hdl.handle.net/2115/70164

このアイテムのアクセス数:770件（2026-10-17 00:11 集計）

閲覧可能ファイル 

ファイル フォーマット サイズ 閲覧回数 説明
1-s2.0-S221315821730284X-mmc1 docx 4.04 MB 345 Supplementary data
1-s2.0-S221315821730284X-main pdf 370 KB 614

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権
open access
URI
https://hdl.handle.net/2115/70164
タイトル
The effect of duration of illness and antipsychotics on subcortical volumes in schizophrenia : Analysis of 778 subjects
著者
Hashimoto, Naoki ; Ito, Yoichi M. ; Okada, Naohiro ; Yamamori, Hidenaga ; Yasuda, Yuka ; Fujimoto, Michiko ; Kudo, Noriko ; Takemura, Ariyoshi ; Son, Shuraku ; Narita, Hisashi ; Yamamoto, Maeri ; Tha, Khin Khin ; Katsuki, Asuka ; Ohi, Kazutaka ; Yamashita, Fumio ; Koike, Shinsuke ; Takahashi, Tsutomu ; Nemoto, Kiyotaka ; Fukunaga, Masaki ; Onitsuka, Toshiaki ; Watanabe, Yoshiyuki ; Yamasue, Hidenori ; Suzuki, Michio ; Kasai, Kiyoto ; Kusumi, Ichiro ; Hashimoto, Ryota
著者名
Hashimoto, Naoki
e-Rad_Researcher
10334236
著者名
Ito, Yoichi M.
著者名
Okada, Naohiro
著者名
Yamamori, Hidenaga
著者名
Yasuda, Yuka
著者名
Fujimoto, Michiko
著者名
Kudo, Noriko
著者名
Takemura, Ariyoshi
著者名
Son, Shuraku
著者名
Narita, Hisashi
著者名
Yamamoto, Maeri
e-Rad_Researcher
20451445
著者名
Tha, Khin Khin
著者名
Katsuki, Asuka
著者名
Ohi, Kazutaka
著者名
Yamashita, Fumio
著者名
Koike, Shinsuke
著者名
Takahashi, Tsutomu
著者名
Nemoto, Kiyotaka
著者名
Fukunaga, Masaki
著者名
Onitsuka, Toshiaki
著者名
Watanabe, Yoshiyuki
著者名
Yamasue, Hidenori
著者名
Suzuki, Michio
著者名
Kasai, Kiyoto
e-Rad_Researcher
30250426
著者名
Kusumi, Ichiro
著者名
Hashimoto, Ryota
言語
英語
キーワード
Schizophrenia
MRI
Globus pallidus
Hippocampus
Antipsychotic
Duration of illness
発行日
2018
出版者
Elsevier
収録物名
NeuroImage : Clinical
巻(号)
17
ページ
563-569
抄録
Background: The effect of duration of illness and antipsychotic medication on the volumes of subcortical structures in schizophrenia is inconsistent among previous reports. We implemented a large sample analysis utilizing clinical data from 11 institutions in a previous meta-analysis. Methods: Imaging and clinical data of 778 schizophrenia subjects were taken from a prospective meta-analysis conducted by the COCORO consortium in Japan. The effect of duration of illness and daily dose and type of antipsychotics were assessed using the linear mixed effect model where the volumes of subcortical structures computed by FreeSurfer were used as a dependent variable and age, sex, duration of illness, daily dose of antipsychotics and intracranial volume were used as independent variables, and the type of protocol was incorporated as a random effect for intercept. The statistical significance of fixed-effect of dependent variable was assessed. Results: Daily dose of antipsychotics was positively associated with left globus pallidus volume and negatively associated with right hippocampus. It was also positively associated with laterality index of globus pallidus. Duration of illness was positively associated with bilateral globus pallidus volumes. Type of antipsychotics did not have any effect on the subcortical volumes. Discussion: A large sample size, uniform data collection methodology and robust statistical analysis are strengths of the current study. This result suggests that we need special attention to discuss about relationship between subcortical regional brain volumes and pathophysiology of schizophrenia because regional brain volumes may be affected by antipsychotic medication.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN
2213-1582
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1016/j.nicl.2017.11.004