Antigenic diversity of H5 highly pathogenic avian influenza viruses of clade 2.3.4.4 isolated in Asia

Ohkawara, Ayako; Okamatsu, Masatoshi; Ozawa, Makoto et al.

Microbiology and immunology, 2017, 61(5), 149-158

Permalink : https://hdl.handle.net/2115/70273

このアイテムのアクセス数:884件（2026-08-16 20:28 集計）

閲覧可能ファイル 

ファイル フォーマット サイズ 閲覧回数 説明
Ohkawara Manuscript revise170217_1 pdf 286 KB 699

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権
open access
URI
https://hdl.handle.net/2115/70273
タイトル
Antigenic diversity of H5 highly pathogenic avian influenza viruses of clade 2.3.4.4 isolated in Asia
著者
Ohkawara, Ayako ; Okamatsu, Masatoshi ; Ozawa, Makoto ; Chu, Duc-Huy ; Lam Thanh Nguyen ; Hiono, Takahiro ; Matsuno, Keita ; Kida, Hiroshi ; Sakoda, Yoshihiro
著者名
Ohkawara, Ayako
e-Rad_Researcher
00507163
著者名
Okamatsu, Masatoshi
著者名
Ozawa, Makoto
著者名
Chu, Duc-Huy
著者名
Lam Thanh Nguyen
著者名
Hiono, Takahiro
e-Rad_Researcher
40753306
著者名
Matsuno, Keita
e-Rad_Researcher
10109506
著者名
Kida, Hiroshi
e-Rad_Researcher
40333637
著者名
Sakoda, Yoshihiro
言語
英語
キーワード
antigenicity
H5N8
hemagglutinin
highly pathogenic avian influenza virus
発行日
2017-05-17
出版者
John Wiley & Sons
収録物名
Microbiology and immunology
巻(号)
61(5)
ページ
149-158
抄録
H5 highly pathogenic avian influenza viruses (HPAIV) have spread in both poultry and wild birds since late 2003. Continued circulation of HPAIV in poultry in several regions of the world has led to antigenic drift. In the present study, we analyzed the antigenic properties of H5 HPAIV isolated in Asia using four neutralizing mAbs recognizing hemagglutinin, which were established using A/chicken/Kumamoto/1‐7/2014 (H5N8), belonging to clade 2.3.4.4 and also using polyclonal antibodies. Viruses of clades 1.1, 2.3.2.1, 2.3.4, and 2.3.4.4 had different reactivity patterns to the panel of mAbs, thereby indicating that the antigenicity of the viruses of clade 2.3.4.4 were similar but differed from the other clades. In particular, the antigenicity of the viruses of clade 2.3.4.4 differed from those of the viruses of clades 2.3.4 and 2.3.2.1, which suggests that the recent H5 HPAIV have further evolved antigenically divergent. In addition, reactivity of antiserum suggests that the antigenicity of viruses of clade 2.3.4.4 differed slightly among groups A, B, and C. Vaccines are still used in poultry in endemic countries, so the antigenicity of H5 HPAIV should be monitored continually to facilitate control of avian influenza. The panel of mAbs established in the present study will be useful for detecting antigenic drift in the H5 viruses that emerge from the current strains.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
This is the peer reviewed version of the following article: "Antigenic diversity of H5 highly pathogenic avian influenza viruses of clade 2.3.4.4 isolated in Asia", which has been published in final form at "https://doi.org/10.1111/1348-0421.12478" . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
PISSN
0385-5600
NCID
AA00738350
関連情報
PMID
28370432
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1111/1348-0421.12478