Effects of childbirth on podocyturia in women with normotensive, uncomplicated pregnancies

Furuta, Itsuko; Zhai, Tianyue; Umazume, Takeshi; Ishikawa, Satoshi; Nakagawa, Kinuko; Kojima, Takashi; Yamada, Takahiro; Morikawa, Mamoru; Minakami, Hisanori

Effects of childbirth on podocyturia in women with normotensive, uncomplicated pregnancies

Furuta, Itsuko; Zhai, Tianyue; Umazume, Takeshi et al.

American Journal of Physiology. Renal Physiology, 2017, 312(6), F1112-F1119

Permalink : https://hdl.handle.net/2115/70642

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アクセス権	open access
URI	https://hdl.handle.net/2115/70642
タイトル	Effects of childbirth on podocyturia in women with normotensive, uncomplicated pregnancies
著者	Furuta, Itsuko ; Zhai, Tianyue ; Umazume, Takeshi ; Ishikawa, Satoshi ; Nakagawa, Kinuko ; Kojima, Takashi ; Yamada, Takahiro ; Morikawa, Mamoru ; Minakami, Hisanori
e-Rad_Researcher 70238682 著者名 Furuta, Itsuko
著者名 Zhai, Tianyue
e-Rad_Researcher 00807935 著者名 Umazume, Takeshi
著者名 Ishikawa, Satoshi
著者名 Nakagawa, Kinuko
著者名 Kojima, Takashi
e-Rad_Researcher 20419948 著者名 Yamada, Takahiro
e-Rad_Researcher 00374380 著者名 Morikawa, Mamoru
e-Rad_Researcher 40102256 著者名 Minakami, Hisanori
言語	英語
キーワード	aquaporin
	podocin
	nephrin
	podocyte injury
	proteinuric disease
発行日	2017-06
出版者	American Physiological Society
収録物名	American Journal of Physiology. Renal Physiology
巻(号)	312(6)
ページ	F1112-F1119
抄録	Changes in hemodynamics and blood pressure occur shortly before and after childbirth regardless of the mode of delivery. This study aimed to test the hypothesis that parturition induces a temporal increase in podocyturia monitored by podocyte-specific protein podocin mRNA expression levels (Pod-mRNA). A total of 105 urine specimens, consisting of 43 and 62 from 18 and 20 otherwise healthy women with vaginal delivery (VD) and elective cesarean delivery (ECS), respectively, were studied. Determination of urine protein and creatinine (Cr) concentrations and quantitative analyses of Pod-mRNA, nephrin mRNA (Nep-mRNA), synaptopodin mRNA (Syn-mRNA), and aquaporin 2 mRNA expression were performed using RT-PCR in pelleted urine samples. Levels of mRNA expression were corrected by urine Cr concentration. Podocyturia increased significantly, concomitant with a significantly decreased Nep:Pod-mRNA ratio (NPR) in the urine, collected immediately before or after childbirth regardless of the delivery mode compared with urine collected before commencement of labor or on postpartum day 3 or later. Podocyturia was significantly negatively correlated with NPR [correlation coefficient (r) = -0.614/-0.750 for VD/ECS women, respectively], as well as the Syn:Pod-mRNA ratio. Systolic blood pressure exceeded 140 mmHg during labor in 50% of VD women, and mean arterial pressure was significantly positively correlated with podocyturia during labor in VD women (r = 0.733). Thus parturition induces a transient increase in urine podocytes with reduced Nep- and Syn-mRNA expressions. Glomerular podocytes with reduced Nep- and Syn-mRNA levels were suggested to be likely to detach from the glomerular basement membrane around childbirth.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	1931-857X
関連情報	PMID 28274928
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1152/ajprenal.00623.2016