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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/70659
タイトル	Asymmetric Synthesis of beta-Lactams through Copper-Catalyzed Alkyne-Nitrone Coupling with a Prolinol-Phosphine Chiral Ligand
著者	Takayama, Yurie ; Ishii, Takaoki ; Ohmiya, Hirohisa ; Iwai, Tomohiro ; Schwarzer, Martin C. ; Mori, Seiji ; Taniguchi, Tohru ; Monde, Kenji ; Sawamura, Masaya
著者名 Takayama, Yurie
著者名 Ishii, Takaoki
e-Rad_Researcher 40508876 著者名 Ohmiya, Hirohisa
e-Rad_Researcher 30610729 著者名 Iwai, Tomohiro
著者名 Schwarzer, Martin C.
著者名 Mori, Seiji
e-Rad_Researcher 00587123 著者名 Taniguchi, Tohru
e-Rad_Researcher 40210207 著者名 Monde, Kenji
e-Rad_Researcher 40202105 著者名 Sawamura, Masaya
言語	英語
キーワード	asymmetric catalysis
	cooperative catalysis
	copper
	nitrones
	beta-lactam
発行日	2017-06-22
出版者	Wiley-Blackwell
収録物名	Chemistry-A European journal
巻(号)	23(35)
ページ	8400-8404
抄録	Prolinol-phosphine chiral ligands enabled highly enantioselective copper-catalyzed intermolecular alkyne-nitrone coupling (Kinugasa reaction) to produce 1,3,4-trisubstituted chiral beta-lactams. A high level of enantiocontrol was achieved not only with aryl-or alkenylacetylenes but also with alkylacetylenes, which were important but unfavorable substrates in the previously reported protocols. Two-point hydrogen bonding between the chiral ligand and the nitrone oxyanion consisting of O-H center dot center dot center dot O and C(sp(3)) H center dot center dot center dot O hydrogen bonds is proposed.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is the peer reviewed version of the following article: Y. Takayama, T. Ishii, H. Ohmiya, T. Iwai, M. C. Schwarzer, S. Mori, T. Taniguchi, K. Monde, M. Sawamura, Chem. Eur. J. 2017, 23, 8400, which has been published in final form at doi:10.1002/chem.201702070. This article may be used for non-commercial purposes in accordance With Wiley-VCH Terms and Conditions for Self-archiving.
PISSN	0947-6539
関連情報	PMID 28488338
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1002/chem.201702070

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