open access

https://hdl.handle.net/2115/70790

Inflammatory Responses in Brain Ischemia

英語

stroke

2015

Bentham Science Publishers

Current Medicinal Chemistry

22(10)

1258-1277

Brain infarction causes tissue death by ischemia due to occlusion of a cerebral artery and recent work has shown that inflammatory responses following ischemia play important roles in the development of ischemic cascade. Because secondary damage by brain inflammation seems to have longer therapeutic time window comparing to the rescue of primary damage by arterial occlusion, controlling the inflammation would be a promising therapeutic target and large amount of experimentally progresses have been made in the past years. However, it is quite difficult to elucidate the precise mechanisms of the inflammatory responses following ischemic stroke because inflammation is a dynamic process involving a complicated set of interactions among various inflammatory cells and molecules, and they could be either detrimental or beneficial. This review will focuses on some recent advances regarding the different key players in neuroinflammation regulating inflammatory signaling pathways, the detrimental effects of post-ischemic inflammation, and the potential molecular targets for ischemic stroke therapy. A better understanding of the roles of the different immune cells and their temporal profile of damage versus repair will help to clarify more effective modulation of inflammation post stroke.

学術雑誌論文

Accepted Manuscript

The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/0929867322666150209154036.

0929-8673