Chronological differential effects of pro-inflammatory cytokines on RANKL-induced osteoclast differentiation of canine bone marrow-derived macrophages

Wijekoon, Suranji; Bwalya, Eugene C.; Fang, Jing; Kim, Sangho; Hosoya, Kenji; Okumura, Masahiro

Chronological differential effects of pro-inflammatory cytokines on RANKL-induced osteoclast differentiation of canine bone marrow-derived macrophages

Wijekoon, Suranji; Bwalya, Eugene C.; Fang, Jing et al.

Journal of veterinary medical science, 2017, 79(12), 2030-2035

Permalink : https://hdl.handle.net/2115/70810

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アクセス権	open access
URI	https://hdl.handle.net/2115/70810
タイトル	Chronological differential effects of pro-inflammatory cytokines on RANKL-induced osteoclast differentiation of canine bone marrow-derived macrophages
著者	Wijekoon, Suranji ; Bwalya, Eugene C. ; Fang, Jing ; Kim, Sangho ; Hosoya, Kenji ; Okumura, Masahiro
著者名 Wijekoon, Suranji
著者名 Bwalya, Eugene C.
著者名 Fang, Jing
著者名 Kim, Sangho
著者名 Hosoya, Kenji
e-Rad_Researcher 80260397 著者名 Okumura, Masahiro
言語	英語
キーワード	cytokine
	dog
	osteoclast
	osteoclastogenesis
	rheumatoid arthritis
発行日	2017-12
出版者	公益社団法人日本獣医学会
出版者	The Japanese Society of Veterinary Science
収録物名	Journal of veterinary medical science
巻(号)	79(12)
ページ	2030-2035
抄録	The aim of this study was to investigate osteoclastogenic properties of inflammatory cytokines at different time-points of osteoclastogenesis. Bone marrow-derived macrophages from five healthy dogs were stimulated with the macrophage colony-stimulating factor, receptor activator of nuclear factor-kappa B ligand and inflammatory cytokines such as interleukin (IL)-1 beta, tumor necrosis factor (TNF)-alpha and IL-17. Osteoclasts (OC) formation and function were enhanced with TNF-alpha regardless of temporal differences. But in contrast, IL-1 beta suppressed the osteoclastogenesis at early phase of the process while upregulating at the late phase. Furthermore, differentiation of OC precursors into OC was suppressed at high concentrations of IL-17. Collectively, the results revealed that suppressing TNF-alpha would be a promising strategy to inhibit inflammation-associated bone destruction in dogs.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2017 The Japanese Society of Veterinary Science
PISSN	0916-7250
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1292/jvms.17-0393