Prevalence and Risk of Birth Defects Observed in a Prospective Cohort Study : The Hokkaido Study on Environment and Children's Health

Hanaoka, Tomoyuki; Tamura, Naomi; Ito, Kumiko; Sasaki, Seiko; Araki, Atsuko; Ikeno, Tamiko; Miyashita, Chihiro; Ito, Sachiko; Minakami, Hisanori; Cho, Kazutoshi; Endo, Toshiaki; Baba, Tsuyoshi; Miyamoto, Toshinobu; Sengoku, Kazuo; Kishi, Reiko; other members of the Hokkaido Study on Environment and Children's Health

Prevalence and Risk of Birth Defects Observed in a Prospective Cohort Study : The Hokkaido Study on Environment and Children's Health

Hanaoka, Tomoyuki; Tamura, Naomi; Ito, Kumiko et al.

Journal of epidemiology, 2018, 28(3), 125-132

Permalink : https://hdl.handle.net/2115/70869

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アクセス権	open access
URI	https://hdl.handle.net/2115/70869
タイトル	Prevalence and Risk of Birth Defects Observed in a Prospective Cohort Study : The Hokkaido Study on Environment and Children's Health
著者	Hanaoka, Tomoyuki ; Tamura, Naomi ; Ito, Kumiko ; Sasaki, Seiko ; Araki, Atsuko ; Ikeno, Tamiko ; Miyashita, Chihiro ; Ito, Sachiko ; Minakami, Hisanori ; Cho, Kazutoshi ; Endo, Toshiaki ; Baba, Tsuyoshi ; Miyamoto, Toshinobu ; Sengoku, Kazuo ; Kishi, Reiko ; other members of the Hokkaido Study on Environment and Children's Health
著者名 Hanaoka, Tomoyuki
e-Rad_Researcher 80836164 著者名 Tamura, Naomi
著者名 Ito, Kumiko
e-Rad_Researcher 30448831 著者名 Sasaki, Seiko
e-Rad_Researcher 00619885 著者名 Araki, Atsuko
e-Rad_Researcher 80569715 著者名 Ikeno, Tamiko
e-Rad_Researcher 70632389 著者名 Miyashita, Chihiro
著者名 Ito, Sachiko
e-Rad_Researcher 40102256 著者名 Minakami, Hisanori
e-Rad_Researcher 10312365 著者名 Cho, Kazutoshi
e-Rad_Researcher 90213595 著者名 Endo, Toshiaki
著者名 Baba, Tsuyoshi
e-Rad_Researcher 70360998 著者名 Miyamoto, Toshinobu
e-Rad_Researcher 30163124 著者名 Sengoku, Kazuo
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
著者名 other members of the Hokkaido Study on Environment and Children's Health
言語	英語
キーワード	Hokkaido Study on Environment and Children's Health
	prospective studies
	cohort studies
	birth defects
	growth retardation
発行日	2018-03-05
出版者	Japan Epidemiological Association
収録物名	Journal of epidemiology
巻(号)	28(3)
ページ	125-132
抄録	Background: Prevalence rates of all anomalies classified as birth defects, including those identified before the 22nd gestational week, are limited in published reports, including those from the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR). In our birth cohort study, we collected the data for all birth defects after 12 weeks of gestation. Methods: Subjects in this study comprised 19,244 pregnant women who visited one of 37 associated hospitals in the Hokkaido Prefecture from 2003 through 2012, and completed follow-up. All birth defects after 12 weeks of gestation, including 55 marker anomalies associated with environmental chemical exposures, were recorded. We examined parental risk factors for birth defects and the association between birth defects and risk of growth retardation. Results: Prevalence of all birth defects was 18.9/1,000 births. The proportion of patients with birth defects delivered between 12 and 21 weeks of gestation was approximately one-tenth of all patients with birth defects. Among those with congenital malformation of the nerve system, 39% were delivered before 22 weeks of gestation. All patients with anencephaly and encephalocele were delivered before 22 weeks of gestation. We observed different patterns of parental risk factors between birth defect cases included in ISBDSR and cases not included. Cases included in ISBDSR were associated with an increased risk of preterm birth. Cases not included in ISBDSR were associated with an increased risk of being small for gestational age at term. Conclusions: Data from our study complemented the data from ICBDSR. We recommend that birth defects not included in ICBDSR also be analyzed to elucidate the etiology of birth defects.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	0917-5040
EISSN	1349-9092
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.2188/jea.JE20160108